click here to print this page

Basak, S., D. Speicher, S. Eck, W. Wunner, G. Maul, M.S. Simmons, and D. Herlyn. 1998. Colorectal carcinoma invasion inhibition by CO17-1A/GA733 antigen and its murine homologue. J Natl Cancer Inst. 90:691-697.

Staib, L., H. Braumuller, C. Leeser, H.G. Beger, R. Somasundaram, W. Li, B. Birebent, and D. Herlyn. 1998. [1st successful immunization of pancreas and colorectal carcinoma patients with CO17-1A-vaccine]. Langenbecks Arch Chir Suppl Kongressbd. 115:53-58.

Herlyn, D. and Birebent, B. 1999. Advances in cancer vaccine development. Ann. Med. 31: 66-78.

Trebak, M., Chong, J.M., Herlyn, D., and Speicher, D.W. 1999. Efficient laboratory-scale production of monoclonal antibodies using membrane-based high-density cell culture technology. J. Immunol. Meth. 230: 59-70.

Somasundaram, R., Robbins, P., Moonka, D., Loh, E., Marincola, F., Patel, A., Guerry, D., and Herlyn, D. 2000. CD4+, HLA class I-restricted, cytolytic T-lymphocyte clone against primary malignant melanoma cells. Int. J. Cancer 85: 253-259.

Daly, T.D., Royal, R.E., Kershaw, M.H., Treisman, J., Wang, G., Li, W., Herlyn, D., Eshhar, Z., Rosenberg, S.A., and Hwu, P. 2000. Recognition of human colon cancer by T cells transduced with a chimeric receptor gene. Cancer Gene Ther. 7: 284-291.

Maruyama, H., Zaloudik, J., Li, W., Sperlagh, M., Koido, T., Somasundaram, R., Scheck, S., Prewett, M., and Herlyn, D. 2000. Point and counterpoint. Cancer vaccines: single epitope anti-idiotype vaccine versus multiple epitope antigen vaccine. Cancer Immunol. Immunother. 49: 123-132.

Basak, S., Eck, S., Gutzmer, R., Smith, A.J., Birebent, B., Purev, E., Staib, L., Somasundaram, R., Zaloudik, J., Li, W., Jacob, L., Mitchell, E., Speicher, D., and Herlyn, D. 2000. Colorectal cancer vaccines: anti-idiotypic antibody, recombinant protein, and viral vector. Ann. N.Y. Acad. Sci. 910: 237-253.

Li, J., Pereira, S., VanBelle, P., Tsui, P., Elder, D., Speicher, D., Deen, K., Linnenbach, A., Somasundaram, R., Swoboda, R., and Herlyn, D. 2001. Isolation of the melanoma-associated antigen p23 using antibody phage display. J. Immunol. 166: 432-438.

Staib, L., Birebent, B., Somasundaram, R., Purev, E., Braumüller, H., Leeser, C., Küttner, N., Li, W., Zhu, D., Wunner, W., Speicher, D., Beger, H-G., Song, H., Diao, J., and Herlyn, D. 2001. Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastrointestinal carcinoma patients. Int. J. Cancer 92: 79-87.

Trebak, M., Begg, G.E., Chong, J.M., Kanazireva, E.V., Herlyn, D., and Speicher, D.W. 2001. Oligomeric state of the colon carcinoma-associated glycoprotein GA733-2 (Ep-CAM/EGP40) and its role in GA733-mediated homotypic cell-cell adhesion. 2001. J. Biol. Chem. 276: 2299-2309.

Birebent, B., Somasundaram, R., Purev, E., Akis, N., Li. W., Mitchell, E., Hoey, D., Bloom, E., Mastrangelo, M., Maguire, H., Harris, D.T., Staib, L., Braumuller, H., Leeser, C., Kuttner, N., Beger, H-G., and Herlyn, D. 2001. Anti-idiotypic antibody and recombinant antigen vaccines in colorectal cancer patients. Crit. Rev. Oncol. Hematol. 39: 107-113.

Birebent, B., Mitchell, E., Li, W., Akis, N., Somasundaram, R., Purev, E., Bloom, E., Mastrangelo, M., Maguire, H., Nair, S., Cai, D., and Herlyn, D. 2001. Monoclonal anti-idiotypic antibody mimicking the gastrointestinal carcinoma-associated epitope CO17-1A elicits antigen-specific humoral and cellular immune responses in colorectal cancer patients. Clin. Cancer Res., in press.

Somasundaram, R., Jacob, L., Basak, S., Monos, D., Peritt, D., Marincola, F., Mastrangelo, M., Hart, E., and Herlyn, D. 2001. Cytolytic and non-cytolytic T-cell lines against colorectal carcinoma. Submitted.

Maruyama, H., M. Sperlagh, J. Zaloudik, S. Liang, K. Mizuki, C. Molthoff, and D. Herlyn. 2002. Immunization procedures for anti-idiotypic antibody induction in mice and rats. J Immunol Methods. 264:121-133.

Somasundaram, R., L. Jacob, R. Swoboda, L. Caputo, H. Song, S. Basak, D. Monos, D. Peritt, F. Marincola, D. Cai, B. Birebent, E. Bloome, J. Kim, K. Berencsi, M. Mastrangelo, and D. Herlyn. 2002. Inhibition of cytolytic T lymphocyte proliferation by autologous CD4+/CD25+ regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-beta. Cancer Res. 62:5267-5272.

Zaloudik, J., W. Li, L. Jacob, M.P. Kieny, R. Somasundaram, B. Acres, H. Song, T. Zhang, J. Li, and D. Herlyn. 2002. Inhibition of tumor growth by recombinant vaccinia virus expressing GA733/CO17-1A/EpCAM/KSA/KS1-4 antigen in mice. Cancer Gene Ther. 9:382-389.

Basak, S., B. Birebent, E. Purev, R. Somasundaram, H. Maruyama, J. Zaloudik, R. Swoboda, W. Strittmatter, W. Li, A. Luckenbach, H. Song, J. Li, K. Sproesser, D. Guerry, S. Nair, K. Furukawa, and D. Herlyn. 2003. Induction of cellular immunity by anti-idiotypic antibodies mimicking GD2 ganglioside. Cancer Immunol Immunother. 52:145-154.

Birebent, B., E. Mitchell, N. Akis, W. Li, R. Somasundaram, E. Purev, D. Hoey, M. Mastrangelo, H. Maguire, D.T. Harris, S. Nair, D. Cai, T. Zhang, and D.M. Herlyn. 2003. Monoclonal anti-idiotypic antibody mimicking the gastrointestinal carcinoma-associated epitope CO17-1A elicits antigen-specific humoral and cellular immune responses in colorectal cancer patients. Vaccine. 21:1601-1612.

Herlyn, D., B. Birebent, E. Purev, R. Somasundaram, E. Mitchell, H. Maguire, L. Staib, and M. Mastrangelo. 2003. Colon cancer antigen and anti-idiotype vaccines. In Cancer Chemotherapy of Biological Response Modifiers, Annual 21. G. Giaccone, R. Schilsky, and P. Sondel, editors. Elsevier Publishing. 287-298.

Kim, J.H., D. Herlyn, K.K. Wong, D.C. Park, J.O. Schorge, K.H. Lu, S.J. Skates, D.W. Cramer, R.S. Berkowitz, and S.C. Mok. 2003. Identification of epithelial cell adhesion molecule autoantibody in patients with ovarian cancer. Clin Cancer Res. 9:4782-4791.

Kirman, I., N. Poltoratskaia, D. Herlyn, and R.L. Whelan. 2003. Addition of interleukin-12 to GA733 tumor protein vaccine leads to development of tumor protective immunity despite surgical stress. Surg Endosc. 17:1135-1139.

Li, J., W. Li, S. Liang, D. Cai, M.P. Kieny, L. Jacob, A. Linnenbach, J.W. Abramczuk, H. Bender, K. Sproesser, R. Swoboda, R. Somasundaram, D. Guerry, and D. Herlyn. 2003. Recombinant CD63/ME491/neuroglandular/NKI/C-3 antigen inhibits growth of established tumors in transgenic mice. J Immunol. 171:2922-2929.

Somasundaram, R., R. Swoboda, L. Caputo, A. Lee, N. Jackson, F.M. Marincola, D. Guerry, and D. Herlyn. 2003. A CD4+, HLA-DR7-restricted T-helper lymphocyte clone recognizes an antigen shared by human malignant melanoma and glioma. Int J Cancer. 104:362-368.

Meng, S., D. Tripathy, S. Shete, R. Ashfaq, B. Haley, S. Perkins, P. Beitsch, A. Khan, D. Euhus, C. Osborne, E. Frenkel, S. Hoover, M. Leitch, E. Clifford, E. Vitetta, L. Morrison, D. Herlyn, L.W. Terstappen, T. Fleming, T. Fehm, T. Tucker, N. Lane, J. Wang, and J. Uhr. 2004. HER-2 gene amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci USA. 101:9393-9398.

Purev, E., D. Cai, E. Miller, R. Swoboda, T. Mayer, A. Klein-Szanto, F.M. Marincola, R. Mick, L. Otvos, W. Wunner, B. Birebent, R. Somasundaram, C.J. Wikstrand, D. Bigner, A. DeMichele, G. Acs, J.A. Berlin, and D. Herlyn. 2004. Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, DeltaEGF-R, and de2-7 EGF-R). J Immunol. 173:6472-6480.

Somasundaram, R., K. Satyamoorthy, L. Caputo, H. Yssel, and D. Herlyn. 2004. Detection of HLA class II-dependent T helper antigen using antigen phage display. Clin Exp Immunol. 135:247-252.

Somasundaram, R., T. Zhang, and D. Herlyn. 2004. Analysis of humoral immune responses in vaccine trials. In Handbook of Cancer Vaccines. M.A. Morse, T.M. Clay, and H.K. Lyerly, editors. Humana Press, Totowa, NJ. pp. 543-561.

Meng, S., D. Tripathy, E.P. Frenkel, S. Shete, E.Z. Naftalis, J.F. Huth, P.D. Beitsch, M. Leitch, S. Hoover, D. Euhus, B. Haley, L. Morrison, T.P. Fleming, D. Herlyn, L.W. Terstappen, T. Fehm, T.F. Tucker, N. Lane, J. Wang, and J.W. Uhr. 2004. Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res 10:8152-62.

Zhang, T., R. Somasundaram, K. Berencsi, L. Caputo, P. Rani, D. Guerry, E. Furth, B.J. Rollins, M. Putt, P. Gimotty, R. Swoboda, M. Herlyn, and D. Herlyn. 2005. CXC Chemokine Ligand 12 (Stromal Cell-Derived Factor 1{alpha}) and CXCR4-Dependent Migration of CTLs toward Melanoma Cells in Organotypic Culture. J Immunol. 174:5856-63.

Gesierich S., C. Paret, D. Hildebrand, J. Weitz, K. Zgraggen,F.H. Schmitz-Winnenthal , V. Horejsi, O. Yoshie, D. Herlyn, LK. Ashman, and M. Zoller 2005. Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. Clin Cancer Res. 11:2840-52.

Somasundaram, R, Caputo, L, Guerry, D, and Herlyn, D. 2005. CD8+, HLA-unrestricted, cytotoxic T-lymphocyte line against malignant melanoma. J Transl Med 3:41.

Furth, E.E., Li, J., Purev, E., Solomon, A.C., Rogler, G., Mick, R., Putt, M., Zhang, T., Somasundaram, R., Swoboda, R., and Herlyn, D. 2006. Serum antibodies to EpCAM in healthy donors but not ulcerative colitis patients. Cancer Immunol Immunother. 55:528-537.

Zhang, T., Somasundaram, R., Berencsi, K., Caputo, L., Gimotty, P., Rani, P., Guerry, D., Swoboda, R., and Herlyn, D. 2006. Migration of cytotoxic T lymphocytes toward melanoma cells in three-dimensional organotypic culture is dependent on CCL2 and CCR4. Eur J Immunol 36:457-467.

Somasundaram, R., Swoboda, R., Caputo, L., Otvos, L., Weber, B., Volpe, P., van Belle, P., Hotz, S., Elder, D.E., Marincola, F.M., Schuchter, L., Guerry, D., Czerniecki, B.J., and Herlyn, D. 2006. Human Leukocyte Antigen-A2-restricted CTL responses to mutated BRAF peptides in melanoma patients. Cancer Res 66:3287-93.

Wei, Q, Clarke, L, Scheidenhelm, DK, Qian, B, Tong, A, Sabha, N, Karim, Z, Bock, NA, Reti, R, Swoboda, R, Purev, E, Lavoie, J-F, Bajenaru, ML, Shannon, P, Herlyn, D, Kaplan, D, Henkelman, RM, Gutmann, DH, and Guha, A. 2006. High-grade glioma formation results from postnatal Pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Res. 66:7429-7437.

Zhang, T., R. Somasundaram, L. Caputo, P. Van Belle, D. Elder, B. Czerniecki, S. Hotz, L. Schuchter, F.R. Spitz, K. Berencsi, P. Rani, F. Marincola, R. Qiu, and D. Herlyn. 2006. Preferential involvement of CX chemokine receptor 4 and CX chemokine ligand 12 in T-cell migration toward melanoma cells. Cancer Biol. Ther. 5:1304-1312.

Meng, S., Tripathy, D., Shete, S., Ashfaq, R., Saboorian, H., Haley, B., Frenkel, E., Euhus, D., Leitch, M., Osborne, C., Clifford, E., Perkins, S., Beitsch, P., Khan, A., Morrison, L., Herlyn, D., Terstappen, L.W.M.M., Lane, N., Wang, J., and Uhr, J. 2006. uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues. Proc Natl Acad Sci USA 103:17361-17365.

Berencsi, K., N.J. Meropol, J.P. Hoffman, E. Sigurdson, L. Giles, P. Rani, R. Somasundaram, T. Zhang, J. Kalabis, L. Caputo, E. Furth, R. Swoboda, F. Marincola, and D. Herlyn. 2007. Colon carcinoma cells induce CXCL11-dependent migration of CXCR3-expressing cytotoxic T lymphocytes in organotypic culture. Cancer Immunol Immunother. 56: 359-370.

Swoboda, R.K., Somasundaram, R., Caputo, L., Ochoa, E.M., Gimotty, P.A., Marincola, F.M., Van Belle, P., Barth, S., Elder, D., Guerry, D., Czerniecki, B., Schuchter, L., Vonderheide, R.H., and Herlyn, D. 2007. Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display. Cancer Res. 67: 3555-3559.

Wondimu, A., Zhang, T., Kieber-Emmons, T., Gimotty, P., Sproesser, K., Somasundaram, R., Ferrone, S., Tsao, C-Y, and Herlyn, D. Peptides mimicking GD2 ganglioside elicit cellular, humoral and tumor-protective immune responses in mice. Cancer Immunol Immunother, 2007.

Somasundaram, R. and Herlyn, D. 2008. Chemokines and their role in neuroectodermal tumor-host interaction. Seminars in Cancer Biology. In press.

Zhang, T. and Herlyn, D. 2008. Combination of active specific immunotherapy, or adoptive antibody or lymphocyte immunotherapy with chemotherapy in the treatment of cancer. In press.

Swoboda, R.K., Somasundaram, R., Caputo, L., Berencsi, K., von Franzke, P., Taylor, D.D., Marincola, F.M., Meropol, N.J., Sigurdson, E., Miller, E. and Herlyn, D. 2008. Nucleophosmin is recognized by a cytotoxic T cell line derived from a rectal carcinoma patient. Submitted.