Melanoma Cell Lines: RGP-Like

RGP-Like melanoma cell lines.

Cell line

Sex/Age

AJCC stage/ pathologya

Level/
thicknessb (mm)

Mitotic

rate

Sitec

Primary
 reference

Isolation

 
date

WM35

F 24

Stage 1
SSM

RGP/VGP

II/0.69

0.0


scalp/neck


(1,2)


11/17/78

WM1552C

M 72

Stage 3
SSM

RGP/VGP

IV/ 5.92

n.a .

buttock

(3)


02/08/88

WM1575

M 45

Stage x

SSM

RGP/VGP

n.a./1.15

n.a .

thigh

(3)


03/14/88

WM1650

M 30

Stage 4
SSM

RGP/VGP

IV/1.14

n.a .

scalp/neck

(4)


08/04/88

WM1789

M 58

Stage 1
SSM

RGP/VGP

III/0.82

n.a .

back

(3)


08/17/89

WM3208V

F 91

Stage x

n.a .

RGP/VGP

n.a/n.a

n.a .

buttock

(3)

08/10/94

WM3211

M 74

Stage 1

RGP/VGP

n.a/n.a

n.a .

ankle

(3)


08/10/94

 

References:

1. Herlyn , M., Thurin, J., Balaban, G., Bennicelli, J. L., Herlyn, D., Elder, D.,E.,  Clark, W.H., and Koprowski, H. Characteristics of cultured human malanocytes isolated from different stages of tumor progression. Cancer Res. 45: 5670, 1985.

2. Balaban, G., Herlyn, M., Guerry, D., IV, Bartolo, R., Koprowski, H., Clark, W.H., and Nowell, P.C. Cytogenics of human malignant melanoma and premalignant lesions. Cancer Genet. Cytogenet. 11: 428, 1984.

3. Satyamoorthy, K., DeJesus, E., Linnenbach, A.,J., Kraj, B. Kornreich, D.L., Rendel, S., Elder, D., and Herlyn, M. Melanoma cell lines from different stages of progression and their biological and molecular analyses. Melanoma Res. 7: S35, 1997.

4. Easty, D. J., Herlyn, M. and Bennett, D.C. Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis. Int. J. Cancer 60: 129. 1995.

Mutational status of RGP-like melanoma cell lines

 

BRAF

n-ras

k-ras

P53

WM35

V599I

WT

WT

WT

WM1552C

V599E

WT

NT

NT

WM1575

NT

NT

NT

NT

WM1650

WT

NT

NT

NT

WM1789

K600E

WT

WT

NT