Huang, R., Holbert, M., Tarrant, M., Curtet, S., Colquhoun, D., Dancy, B., Dancy, B., Hwang, Y., Tang, Y., Meeth, K., Marmorstein, R., Cole, P., Khochbin, S., Cole, P. “Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.” (2010) J. Am. Chem. Soc. Epub ahead of print.
Bowers E.M., Yan, G., Mukherjee, C., Orry, A., Wang, L. Holbert, M.A. Crump, N.T., Hazzalin, C.A., Liszczak, G., Yuan, H., Larocca, C., Saldanha, S.A. Abagyan, R., Sun, Y., Meyers, D.J. Marmorstein, R., Mahadevan, L.C., Alani, R., Cole, P.A. “Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitor.” (2010) Chemistry & Biology, 17, 471-82.
Ipsaro, J.J., Harper, S.L. Messick, T.E., Marmorstein, R., Mondragon, A., Speicher, D.W. “Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex.” (2010) Blood, 115, 4843-52.
Marmorstein R. “Anticipating drug resistance in the MAP kinase pathway.” (2010) Pigment Cell & Melanoma Research, 23, 7-9.
Yi, C., Maksimoska, J., Marmorstein, R. and Kissil, J.L. “Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer.” (2010) Biochem. Pharmacol., Epub ahead of print.
Sanders, B.D., Jackson, B., Brent, M., Taylor, A.M., Dang, W., Berger. S.L., Schreiber, S.L., Howitz. K and Marmorstein, R., “Identification and characterization of novel sirtuin inhibitor scaffolds.” (2009), Bioorganic Medicinal Chem., 17, 7031-41.
Hait, N.C., Allegood, J.,Maceyka, M., Strub,G.M., Harikumar, K.B., Singh, S.K., Luo, C., Marmorstein, R., Kordula, T., Milstien, S. and Spiegel, S. “Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate.” (2009) Science 325, 1254-7.
Brent, M.M., Iwata, A., Carten, J., Zhao, K. and Marmorstein, R. “Structure and biochemical characterization of protein acetyltransferase (PAT) from Sulfolobus Solfataricus.” (2009) J. Biol. Chem. 284, 19412-9.
Xie, P., Streu, G., Qin, J., Bregman, H., Pagano, N., Meggers, E., Marmorstein, R., “Crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.” (2009) Biochemistry 48, 5187-98.
Anand, R., Maksimoska, J., Pagano, N., Wong, E.Y., Gimotty, P.A., Diamond, S.L., Meggers, E. and Marmorstein, R. “Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor.” (2009) J. Med. Chem. 52,1602-11.
Banumathy, G., Somaiah, N., Zhang, R., Tang, Y., Hoffmann, J., Andrake, M., Ceulemans, H., Schultz, D., Marmorstein, R. and Adams, P. “Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.” (2009) Mol. Cell. Biol. 29, 758-70.
Sanders, B.D. Jackson, B. and Marmorstein, R. “Structural Basis for Sirtuin Function: What We Know and What We Don’t.” (2009) Biochem. Biophysics Acta, 1804, 1604-1616.
Maksimoska, J., Li, F., Harms, K., Yi, C., Kissil, J., Marmorstein, R. And Meggers, E. “Targeting large kinase active sites with rigid, bulky octahedral ruthenium complexes.” (2008) J. Am. Chem. Soc. 130, 15764-5.
Malecka, K.A., Ho, W.C. and Marmorstein, R. “Crystal structure of a p53 core domain tetramer bound to DNA.” (2009) Oncogene 28, 325-33.
Anand, R., Kim, A-Y., Brent, M. and Marmorstein, R. “Biochemical analysis of MST1 kinase: Elucidation of a C-terminal regulatory region.” (2008) Biochemistry 282, 35425-9.
Brent, M.M., Anand, R. and Marmorstein, R. “Structural Basis for DNA Recognition by FoxO1 and its Regulation by Post-Translational Modification.” (2008) Structure, In press.
Tang, Y., Meeth, K., Jiang, E., Luo, C. and Marmorstein, R. “Structure of Vps75 and Implications for Histone Chaperone Function” (2008) Proc. Natl. Acad. Sci., 105, 12206-12211.
Marmorstein, R. and Trievel, R.C. “Histone Modifying Enzymes: Structures, Mechanisms, and Specificities.” (2008) Biochem. Biophysics Acta, Epub ahead of print.
Luo, C., Xie, P. and Marmorstein, R. “Identification of BRAF inhibitors through in silico screening” (2008) J. Med. Chem., In press
Tang, Y., Holbert, M.A., Wurtele, H., Meeth, K., Rocha, W., Gharib, M., Jiang, E., Thibault, P., Verreault, A., Cole, P.A. and Marmorstein, R. “Fungal Rtt109 Histone Acetyltransferase is an Unexpected Structural Homolog of Metazoan p300/CBP” (2008) Nature Struc. Mol. Biol., 15, 738-745.
Hong, M., Fitzgerald, M.X., Harper, S., Luo, C., Speicher, D.W. and Marmorstein, R. “Structural Basis for Dimerization in DNA Recognition by Gal4” (2008)Structure, 16, 1019-1026.
Anand, R., Kim, A-Y., Brent, M. and Marmorstein, R. “Biochemical Analysis of MST1 Kinase: Elucidation of a C-Terminal Regulatory Region” (2008) Biochemistry, In press.
Xie, P., Williams, D.S., Atilla-Gokcumen, G. E., Milk, L., Xiao, M., Smalley, K.S.M., Herlyn, M., Meggers, E., and Marmorstein, R. “Structure-based design of an organoruthenium Phosphatidyl-Inositol-3-Kinase inhibitor reveals a switch governing lipid kinase potency and selectivity” (2008) ACS Chem. Biol., 3, 305-316.
Messick, T.E., Russel, N.S. Awata, A.J., Sarachan, K.L., Shiekhattar, R., Shanks, J.R., Reyes-Turcu, F. E., Wilkinson, K.D. and Marmorstein, R. “Structural basis for ubiquitin recognition by the ovarian tumor domain protein.” (2008) J. Biol. Chem., 283, 11038-11049.
Walter, W., Clynes, D., Tang, Y., Norman, J., Shiekhattar, R., Marmorstein, R., Mellor, J.and Berger, S. “14-3-3 interaction with histone H3 requires dual modification pattern of phosphoacetylation” (2008) Mol. Cell. Biol., 28, 2840-2849.
Kwon, H.-S., Brent, M.M., Getachew, R., Jayakumar, P., Chen, L.F., Schnoelzer, M., McBurney, M.W., Marmorstein, R., Greene, W.C. and Ott, M. “Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T-Cell Hyperactivation”
(2008) Cell Host Microbe, 3, 158-167.
Liu, X., Wang, L., Zhao, K., Thompson, P.R. Hwang, Y., *Marmorstein, R. and *Cole, P.A. “The structural basis of protein acetylation by the p300/CBP transcriptional coactivator.”
(2008) Nature, 451, 846-850. (* shared correspondence)
Brent, M.M. and Marmorstein, R. “Ankyrin for methylated lysines.” (2008) Nature Struc. Mol. Biol., 15, 221-222.
Anand, R. and Marmorstein, R. “Structure and mechanism of lysine specific demethylase enzymes.” (2007) J. Biol. Chem., 282, 35425-35429.
Liu, X. and Marmorstein, R. “Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor.” (2007) Genes Dev., 21, 2711-2716.
Holbert, M.A., Sikorski, T., Carten, J., Snowflack, D., Hodawadekar, S and Marmorstein, R. “The human monocytic leukemia zinc-finger histone acetyltransferase domain contains DNA binding activity implicated in chromatin targeting.” (2007) J. Biol. Chem., 282. 36603-36613.
Li, K., Ossareh-Nazari B., Liu, X., Dargemont, C. and Marmrostein, R. “Molecular basis for Bre5 cofactor recognition by the Ubp3 deubiquitinating enzyme” (2007) J. Mol. Biol., 372, 194-204.
Hodawadekar, S. and Marmorstein, R. “Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design.” (2007) Oncogene, 26, 5528-5540.
Hong, M. and Marmorstein, R. “Structural Basis for Sequence-Specific DNA Recognition by Transcription Factors and their Complexes.” (2008) In Structural Biology of Protein/DNA Interactions (Rice, P.A. and Carol, C.C. eds), 47-65.
Sanders, B.D., Zhao, K., Slama, J.T. and Marmorstein, R. “Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes.” (2007) Mol. Cell, 25, 463-472.
Peng, H.; Gibson, L.C., Capili; D., Borden, K.L., Osborne, M. J., Harper, L., Speicher, D.W., Zhao, K., Marmorstein, R., Rock, T.A. and Rauscher III, F.J. “The Structurally Disordered KRAB Repression Domain is Incorporated into a Protease Resistant Core upon Binding to KAP-1-RBCC Domain.” J. Mol. Biol., 370, 269-289.
Karanam, B., Wang, L., Wang, D., Liu, X., Marmorstein, R., Cotter, R. and Cole, P.A. “Analysis of p300 HAT-ATF-2 Interactions.” (2007) Biochemistry, 46, 8207-8216.
Fitzgerald, M.X., Rojas, J.R., Kim, J.M.,
Kohlhaw, G.B. and Marmorstein, R. “Structure of a Leu3/DNA
complex: Recognition of everted CGG half-sites by a Zn2Cys6
binuclear cluster protein.” (2006) Structure 14, 725-735.
Da, G., Lenkart, J., Zhao, K., Shiekhattar,
R., Cairns, B. and Marmorstein, R. “Structure
and function of the SWIRM domain, a conserved protein module
found in chromatin regulatory complexes.” (2006) Proc. Natl. Acad. Sci. USA. 103, 2057-2062.
Culhane, J.C., Szewczuk, L.M., Liu, X., Da., G., Marmorstein, R. amd Cole, P. “A Mechanism-based inactivator of histone demethylase LSD1.” (2006) J. Am. Chem. Soc. 128, 4536-4537.
Ho, W.C., Fitzgerald, M.X. and Marmorstein, R. “Structure of the p53 core domain dimer bound to DNA.” (2006) J. Biol. Chem., 281, 20494-20502.
Tang, Y., Poustovoitov, M.V., Zhao, K., Garfinkel, M., Canutescu, A., Dunbrack, R., Adams, P.D., and Marmorstein, R. “Structure of a human ASF1a/HIRA complex: Insights into specificity of histone chaperone complex assembly.” (2006) Nature Struc. Mol. Biol., 13, 921-929.
Wilson, J.M., Le, V.Q., Zimmerman, C., Marmorstein, R. and Pillus, L. “Facilitated nuclear export modulates the cytoplamic Sir2Homolog Hst2.” (2006) EMBO Reports, 7, 1247-1251.
Ho, W.C., Luo, C., Zhao, K., Chai, X., Fitzgerald, M.X. and Marmorstein, R. “High resolution structure of the p53 core domain: implications for binding small molecule stabilizing compounds.” (2006) Acta Cryst., 62, 1484-1493.
Sykes, S.M., Mellert, H.S., Holbert, M.A., Li, K., Marmorstein, R., Lane, W.S. and McMahon, S.B. “Acetylation of the p53 DNA-binding domain regulates apoptosis induction.” (2006) Mol. Cell, 24, 841-851.
Zhao, K. and Marmorstein, R. “Protein
co-crystallization for X-ray structure determination”
in Protein-Protein Interactions (Golemis, E. and Adams, P.
eds) Second edition, In press.
Nayak, V., Zhao, K., Lo, S.L., Berger, S. and Marmorstein, R.“Structure of the yeast Snf1 kinase, a member of the Snf1/AMPK protein family.” (2006) Structure 14, 477-485.
Zhao, K. and Marmorstein, R. “Structure
of the Sir2 family of NAD+-dependent histone/protein deactylases.”
In Histone Deacetylases: Transcriptional Regulation and Other
Cellular Functions (Verdin, E. ed) Humana Press., pp 203-218.
Liu, X., Clements, A., Zhao, K. and Marmorstein, R. “Structure of the Human Papillomavirus E7 Oncoprotein and its Mechanism for Inactivation of the Retinoblastoma Tumor Suppressor” (2006) J. Biol. Chem. 281, 578-586.
Liu, X. and Marmorstein, R. “When viral oncoprotein meets tumor suppressor: A structural view.” (2006) Genes Dev., 20, pp 2332-2337.
Emre, N.C.T., Ingvarsdottir, K., Wyce, A.,
Wood, A., Krogan, N.J., Henry, K.W., Li, K., Greenblatt, J.F.,
Marmorstein, R., Shilatifard, A. and Berger, S.L. “Maintenance
of low histone ubiquitylation by Ubp10 correlates with telomereproximal
Sir2 association and gene silencing” (2005) Molecular
Cell, 18, 585-594.
Deng, Z., Atanasiu, C., Zhao, K., Marmorstein,
R., Sbodio, J.I., Chi, N.W. and Lieberman, P.M. “Inhibition
of Epstein-Barr Virus OriP function by tankerase, a telomere-associated
poly-ADP ribose polymerase that binds and modifies EBNA1” (2005) J. Virol., 79, 4640-4650.
Li, K., Zhao, K, Ossareh-Nazari B., Da,
G., Dargemont, C. and Marmrostein, R. “Structural
basis for interaction between the Ubp3 deubiquitinating enzyme
and its Bre5 cofactor” (2005) J. Biol. Chem. 280,
29176-29185.
Wang, W., Ho, W.C., Dicker, D.T., Mackinnon,
C., Winkler, J.D., Marmorstein, R. and El-Deiry, W.C. “Acridine
derivatives activte p53 and induce tumor cell death through
Bax” (2005) Cancer Biol. Ther. 4, pub. ahead of
print.
Liu, X., Clements, A., Zhao, K. and Marmorstein,
R. “Structure
of the Human Papillomavirus E7 Oncoprotein and its Mechanism
for Inactivation of the Retinoblastoma Tumor Suppressor.” (2005) J. Biol. Chem., In press.
Holbert M.A. and Marmorstein, R. “Structure
and activity of enzymes that remove histone modifications.” (2005) Curr. Opin. Struct. Biol., 6, pp673-680.
Marmorstein, R. “Structure
and chemistry of the Sir2 family of NAD+-dependent histone/protein
deactylases.” (2004) Biochemical Society Transactions,
2004 32(Pt 6), pp 904-9.
Zhao, K., Chai, X. and Marmorstein, R. Structure
and substrate binding properties of CobB, a Sir2 homolog protein
deacetylase from Eschericia coli (2004) J.
Mol. Biol., 337, 731-741.
Zhao, K., Harshaw, R. Chai, X. and
Marmorstein, R. Structural
basis for nicotinamide cleavage and ADP-ribose transfer by
NAD +-dependent Sir2 histone/protein deacetylases (2004) Proc. Natl. Acad. Sci. USA, 101, 8563-8568.
Marmorstein, R. Biochemical
and structural characterization of recombinant histone acetyltransferase
proteins. (2004), Methods Enzymol., 376, 106-119.
Marmorstein, R. Structural
and chemical basis of histone acetylation. (2004), inReversible
Protein Acetylation (Bock G. and Goode J. ed) Novartis
Foundation Symposium 259, John Wiley & Sons.,
pp. 78-101.
Poux, A. N. and Marmorstein, R. Molecular
basis for Gcn5/PCAF histone acetyltransferase selectivity
for histone and non-histone substrates (2003) Biochemistry,
In press
Zhao, K., Xiaomei, C. and Marmorstein, R. Structure
of the yeast Hst2 histone deactylase in ternary complex with
2’-O-acetyl ADP ribose and histone peptide (2003)
Structure, 11, 1403-1411.
Zhao, K., Xiaomei, C., Clements, A. and Marmorstein,
R. Structure
and autoregulation of a yeast Hst2 homolog of Sir2 (2003)
Nature Structural Biology., 10, 864-871.
Clements, A, Poux, A, Lo, S., Pillus, L., Berger,
S. L. and Marmorstein, R. Structural
basis for histone and phospho-histone binding by the Gcn5
histone acetyltransferase. (2003) Mol. Cell, 12, 461-473.
Marmorstein, R. Initiation
of transcription at its most basic level. (2003) Cell,
115, 370-372.
Clements, A. and Marmorstein, R. Structure
and function of histone acetyltransferase domains: Insights
into GCN5/PCAF and yEsa1. (2003), Methods Enzymol.,2003;371:545-64
Marmorstein, R. Biochemical
and structural characterization of recombinant histone acetyltransferase
proteins. (2003), Methods Enzymol., 2004;376:106-19
Marmorstein, R. “Structural and chemical
basis of histone acetylation.” (2003), inReversible
Acetylation and Methylation of Chromatin and Non-Histone Proteins:
Biology and Relavance to Human Disease (Novartis Foundation)
John Wiley & Sons., In press
Zhao K, Chai X, Marmorstein R. Structure of a Sir2 substrate, Alba, reveals a mechanism for
deactylation-induced enhancement of DNA-binding. J Biol
Chem. 2003 May 1
Xiao B, Spencer J, Clements A, Ali-Khan N, Mittnacht
S, Broceno C,Burghammer M, Perrakis A, Marmorstein R, Gamblin
SJ. Crystal
structure of the retinoblastoma tumor suppressor protein bound
to E2F and the molecular basis of its regulation. Proc
Natl Acad Sci U S A. 2003 Mar 4;100(5):2363-8.
Marmorstein, R. and Fitzgerald, M.X. R Modulation
of DNA-Binding Domains for Sequence-Specific DNA Recognition.
Gene. 2003 Jan 30;304:1-12. Review.
Marmorstein, R. Structure
of SET domain proteins - a new twist on histone methylation. Trends Biochem Sci. 2003 Feb;28(2):59-62. Review.
Johnston, K, and Marmorstein, R. (2003) Coexpression
of Proteins in E. coli Using Dual Expression Vectors. in Methods in Molceular Biology: E-coli Gene Expression Protocols
(Vaillancourt, P., ed), Vol. 205, Humana Press Inc., pp. 205-213.
Yuan, Y, Harper, S, Speicher, D. and Marmorstein,
R. The Catalytic Mechanism of the Yeast Esa1 Histone Acetyltransferase
Involves a Self-Acetylated Intermediate. (2002) Nature
Strucutral Biology, 11, 862-869.
Poux, A., Cabrat, M., Kim, C.M., Cole. P.A.
and Marmorstein, R. Structure
of the Gcn5 Histone Acetyltransferase Bound to a Bisubstrate
Inhibitor. (2002) Proc. Natl. Acad. Sci. USA, 99, 14065-14070.
Venkataramani, R.N., MacLachlan, T.K, Chai, X.,
El-Deiry, W.S. and Marmorstein, R. Structure-Based
Design of More Stable p18INK4c Proteins with Increased CDK
Inhibitory Activity. (2002), J. Biol. Chem., 277, 48827-48833.
Marmorstein, R. Dehydrogenases,
NAD and Transcription - What's the connection? (2002)
Structure, 10, 1465-1466.
Wlazlo, A.P., Giles-Davis, W., Clements,
A., Struble, G., Marmorstein, R. and Ertl, H.C.J. Generation
and Characterization of Monoclonal Antibodies against the
E6 and E7 Oncoproteins of HPV. (2001) Hybridoma, 20,
257-263.
Mo, Y., Ho W.., Johnston, K., and Marmorstein,
R. Crystal
Structure of a Ternary SAP-1/SRF/c-fos SRE DNA Complex. (2001) J. Mol. Biol., 314, 505 - 516.
Marmorstein, R. Structure
of Histone Deacetylases: Insights into substrate recognition
and catalysis (2001) Structure, 9, 1127-1133.
Marmorstein, R. Structure
of histone acetyltransferases. (2001) J Mol Biol., 311,
433-44.
Marmorstein, R. and Berger. S. L. "Structure
and Function of Bromodomains in Chromatin-Regulating Complexes." (2001) Gene, 272, 1-9
Marmorstein, R. "Protein Modules that Manipulate Histone Tails for Chromatin
Regulation." (2001) Nature Reviews Molecular Cell Biology, 2, 693-703.
Zhao, K., Chai, X., Johnston, K., Clements, A.
and Marmorstein, R. "Crystal structure of the mouse p53 core DNA-binding domain
at 2.7Å resolution," (2001) J. Biol. Chem., 276,
12120-12127.
Marmorstein, R. and Roth, S. "Histone
Acetyltransferases: Function, Structure, and Catalysis." (2001) Curr. Opin. Genet. Devlop., 11, 155-161
Marmorstein, R. "Structure
and Function of Histone Acetyltransferases." (2001) Cell
Mol Life Sci., 58, 693-703
Clements, A., Johnston, K., Mazzarelli,
J. M., Ricciardi, R. P. and Marmorstein, R. "Oligomerization
Properties of the Viral Oncoproteins Adenovirus E1A and Human
Papillomavirus E7 and their Complexes with the Retinoblastoma
Protein." (2000) Biochemistry, 39, 16033-16045.
Trievel, R.C., Li, F.-Y. and Marmorstein, R. Application
of a Fluorescence Histone Acetyltransferase Assay to Probe
the Substrate Specificity of Human PCAF. (2000), Analytical
Biochem., 287, 319-328.
Yan, Y., Barlev, N. A., Haley, R. H., Berger,
S. L. and Marmorstein, R. "Crystal Structure of Yeast Esa1 Suggests a Unified Mechanism
for Catalysis and Substrate Binding by Histone Acetyltransferases." (2000) Mol. Cell, 6, 1195-1205.
Johnston, K., Clements, A., Venkataramani, R.,
Trievel, R. and Marmorstein, R. "High Level Co-expression of Proteins in Bacteria Using T7-Based
Expression Plasmids: Expression of Heteromeric Cell-Cycle
and Transcriptional Regulatory Complexes." (2000), Protein
Expression and Purification, 20, 435-443.
Lukens, A. K., King, D. A. and Marmorstein, R. "Structure
of HAP1-PC7 bound to DNA: implications for DNA recognition
and allosteric effects od DNA-binding on transcriptional activation." (2000) Nucleic Acids Res., 28, 3853-3863.
Lo W-S., Trievel, R., Rojas, J., Duggin, L., Marmorstein,
R. and Berger, S.L. "Phosphorylation of Serine 10 in Histone H3 is Functionally
Linked in vitro and in vivo to GCN5-Mediated
Acetylation at Lysine 14." (2000), Mol. Cell.,5,
917-926.
Mo, Y., Veassen, B., Johnston, K., and Marmorstein,
R. "Elk-1/DNA
structure reveals how DNA-distal residues effect ETS-domain
recognition of DNA." (2000), Nature Struct. Biol. 7: 292-297.
Li, X., Peng, H., Schultz, D.C., Lopez-Guisa,
J., Rauscher, F.J. and Marmorstein, R. "Structure-Function
Studies of the BTB/POZ Transcriptional Repression Domain from
the Promyelocytic Leukemia Zinc Finger Oncoprotein" (1999), Cancer Res. 59, 5275-5282.
Rojas, J.R., Trievel, R.C., Mo, Y., Li, X., Zhou,
J., Berger, S.L., Allis, C.D. and Marmorstein, R. "Crystal Structure of Tetrahymena GCN5 Bound with
Coenzyme-A and Histone H3 peptide." (1999) Nature, 401, 93-97.
Trievel, R.C., Rojas, J.R., Sterner, D.E., Venkataramani,
R., Wang, L., Zhou, J., Allis, Berger, S.L. and Marmorstein,
R. "Crystal Structure and Mechanism of Histone Acetylation
of the Yeast GCN5 Transcriptional Coactivator,"(1999) Proc. Natl. Acad. Sci. USA 96, 8931-8936.
Clements, A., Rojas, J.R., Trievel, R.C., Wang,
L., Berger, S.L. and Marmorstein, R. "Crystal Structure of the Histone Acetyltransferase Domain
of the Human P/CAF Transcriptional Regulator Bound to Coenzyme-A." (1999) EMBO J. 18, 3521-3532.
Tanner, K.G., Trievel, R.C., Kuo, M.-H., Howard,
R., Berger, S.L., Allis, C.D., Marmorstein, R. and Denu, J.M. "Catalytic
Mechanism and Function of Invariant Glutamic Acid-173 from
the Histone Acetyltransferase GCN5 Transcriptional Coactivator." (1999) J. Biol. Chem. 274, 18157-18160.
Liu, L., Scolnick, D.M., Trievel, R.C., Zhang,
H-B., Marmorstein, R., Halazonetis, T.D. and Berger, S.L. "p53
Sites Acetylated in vitro by PCAF and p300 are Acetylated in vivo in Response to DNA Damage" (1999), Mol. Cell. Biol. 19, 1202-1209.
King, D.A., Zhang, L., Guarente, L. and Marmorstein,
R. "Structure of a HAP1/DNA Complex Reveals Dramatically
Asymmetric DNA Binding by a Homodimeric Protein" (1999) Nature Structural Biol. 6, 64-71.
King, D.A., Zhang, L., Guarente, L. and Marmorstein,
R. "Structure of HAP1-18/DNA Implicates Direct Allosteric
Effects of Protein-DNA Interactions onTranscriptional Activation" (1999), Nature Structural Biol. 6, 22-27.
Marmorstein, R. (1998) "Crystallization
of Soluble Macromolecules" in Current Protocols in
Protein Science (Coligan, J.E., Dunn, B., Ploegh, H.L.,
Speicher, D.W., and Wingfield, P.T., eds) Vol. 1, Suppl. 11,
John Wiley & Sons, Inc., pp. 17.4.1-17.4.17.
Marmorstein, R., Venkataramani, R., Swaminathan,
K. (1998). "Structure
of the p18INK4c Protein: Insights into Ankyrin-Like
Repeat Structure/Function and Tumor-Derived p16INK4 Mutations
" in Proceedings of the 17th International Cancer
Congress, (Moras, M., Brentani, R. and Bevilacqua R.,
eds) Vol 1, Monduzzi Editore, pp.159-165.
Mo, Y., Vaessen, B., Johnston, K. and Marmorstein,
R. "Structures of SAP-1 Bound to DNA Sequences from the
E74 and c-fos Promoters Provide Insights Into How Ets Proteins
Discriminate Between Related DNA Targets" (1998), Mol. Cell. 2, 201-212.
Venkataramani, R., Swaminathan, K. and Marmorstein,
R. "Crystal
Structure of the CDK4/6 Inhibitory Protein p18INK4c Provides Insights into Ankyrin-Like Repeat Structure/Function
and Tumor-Derived p16INK4 Mutations" (1998), Nature Structural Biol.. 5, 74-81.
Li, X., Lopez-Guisa, J. M., Ninan, N., Weiner,
E. J., Rauscher, F. J. and Marmorstein, R. "Overexpression,
Purification, Characterization and Crystallization of the
BTB/POZ Domain from the PLZF Oncoprotein" (1997), J. Biol. Chem. 272, 27324-27329.
Swaminathan, K., Flynn, P. Reece, R. J., and Marmorstein,
R. "Crystal Structure of a PUT3-DNA Complex: a Novel Mechanism
for DNA Recognition by a Protein Containing a Zn2Cys6 Binuclear
Cluster" (1997), Nature Structural Biol. 4,
751-759.
Liang, S.L., Marmorstein, R., Harrison, S.C.,
& Ptashne, M., "DNA Sequence Preferences of GAL4 and PPR1: How a Subset
of Zn2Cys6 Binuclear Cluster Proteins Recognize DNA" (1996), Mol. Cell. Biol. 16, 3773-3780.
Marmorstein, R. and Harrison, S.C., "Structure
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