Waking a Sleeping Dragon: Activation of the Myc Oncoprotein

Waking a Sleeping Dragon: Activation of the Myc Oncoprotein

Waking a Sleeping Dragon: Activation of the Myc Oncoprotein

Wednesday, May 2, 2012 - 10:00am

Joseph N. Grossman, M.D. Auditorium
The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104

Robert Neil Eisenman, Ph.D. of the Fred Hutchinson Cancer Research Center will present this lecture.

This event is free and open to the public. For more information, call 215-898-3944.

The Eisenman laboratory is focused on understanding the molecular and biological activities associated with the Myc transcription factor network—a group of proteins profoundly involved in the genesis of many diverse cancers.

In the talk, I will focus on what distinguishes the normal versus oncogenic functions of Myc. I will describe what we consider to be  a "minimally" activating mutation that we have introduced into endogenous c-myc and N-myc genes and discuss our initial findings on the consequences of this mutation for normal development and for neoplastic progression.