Mechanisms of Metastatic Dissemination

Mechanisms of Metastatic Dissemination

Mechanisms of Metastatic Dissemination

Wednesday, May 15, 2013 - 10:00am

Joseph N. Grossman, M.D. Auditorium
The Wistar Institute
3601 Spruce Street
Philadelphia, Pennsylvania 19104

Robert A. Weinberg, Ph.D., of Whitehead Institute for Biomedical Research will present this lecture at 10:00 a.m. in the Grossman Auditorium. 

Free and open to the public. For more information, call 215-898-3944.

Mechanisms of Metastatic Dissemination 

Carcinoma cells undergo a profound phenotypic shift within primary tumors termed the epithelial-mesenchymal transition (EMT), which imparts to them many of the attributes of mesenchymal cells, including motility, invasiveness and a heightened resistance to apoptosis.  This empowers cancer cells to disseminate from primary tumors and, at the same time, to serve as founders of distant metastatic colonies.  This program appears to be triggered by contextual signals that carcinoma cells receive from the nearby stromal microenvironment that is generated as primary tumors develop. The phenotypic changes that the EMT program  confers may be reversed when disseminated carcinoma cells encounter a novel microenvironment in a distant tissues, explaining the histopathologic resemblance between primary tumors and their derived metastases.