Cell line |
Sex/Age |
AJCC stage/ |
Level/ |
Mitotic rate |
Specimen site |
Primary reference |
Isolation |
WM75 |
M 48 |
Stage 3 SSM RGP/VGP |
IV/6.25 |
3.8 |
L back/ chest |
(5-8) |
07/17/79 |
WM98-1 |
M 50 |
Stage 2 SSM RGP/VGP |
IV/5.40 |
6.5 |
chest |
(1,7,8) |
11/30/79 |
WM115 |
F 55 |
Stage n.a. SSM RGP/VGP |
III/2.24 |
10.3 |
groin R leg |
(3,5-8) |
04/30/80 |
WM278 |
F 62 |
Stage 2 NM VGP only |
IV/3.7 |
n.a . |
n.a . |
(1-3,8) |
11/11/81 |
WM740V |
F 34 |
Stage 2 SSM RGP/VGP |
III/3.24 |
n.a . |
chest |
(8) |
n.a . |
WM793B |
M 37 |
Stage 1 SSM RGP/VGP |
II/0.55 |
n.a . |
sternum |
(1,3,5,7,8) |
01/07/83 |
WM853-2 |
M 70 |
Stage 2 SSM RGP/VGP |
IV/3.75 |
n.a . |
back |
(8) |
05/25/83 |
WM902B |
n.a . |
Stage n.a. SSM VGP |
n.a . |
n.a . |
n.a . |
(1,5,7) |
11/14/83 |
WM983A |
M 54 |
Stage n.a. URGP RGP/VGP |
IV/25.0 |
n.a . |
abdomen |
(7,8) |
08/13/84 |
WM1341D |
M 85 |
Stage n.a. LMM RGP/VGP |
IV/3.70 |
n.a . |
n.a . |
n.a . |
07/28/86 |
WM1361A |
M 50 |
Stage x SSM RGP/VGP |
IV/1.22 |
2.2 |
forearm |
(7,8) |
08/27/86 |
WM3268V |
F 70 |
Stage 3 |
n.a . |
n.a . |
leg |
n.a . |
n.a . |
References:
1. Herlyn , M., Thurin, J., Balaban, G., Bennicelli, J. L., Herlyn, D., Elder, D.,E., Clark, W.H., and Koprowski, H. Characteristics of cultured human malanocytes isolated from different stages of tumor progression. Cancer Res. 45: 5670, 1985.
2. Balaban, G., Herlyn, M., Guerry, D., IV, Bartolo, R., Koprowski, H., Clark, W.H., and Nowell, P.C. Cytogenics of human malignant melanoma and premalignant lesions. Cancer Genet. Cytogenet. 11: 428, 1984.
3. Satyamoorthy, K., DeJesus, E., Linnenbach, A.,J., Kraj, B. Kornreich, D.L., Rendel, S., Elder, D., and Herlyn, M. Melanoma cell lines from different stages of progression and their biological and molecular analyses. Melanoma Res. 7: S35, 1997.
4. Easty, D. J., Herlyn, M. and Bennett, D.C. Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis. Int. J. Cancer 60: 129. 1995.
5. Rodeck, U., Herlyn, M., Menssen, H.D., Furlanetto, R.W., Koprowski, H.: Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors. Int J Cancer 40: 687, 1987.
6. Herlyn, M., Balaban, G., Bennicelli, J., Guerry, D.t., Halaban, R., Herlyn, D., Elder, D.E., Maul, G.G., Steplewski, Z., Nowell, P.C., et al.: Primary melanoma cells of the vertical growth phase: similarities to metastatic cells. J Natl Cancer Inst 74:283-289, 1985.
7. Kath, R., Rodeck, U., Parmiter, A., Jambrosic, J., Herlyn, M.: Growth factor independence in vitro of primary melanoma cells from advanced but not early or intermediate lesions. Cancer Therapy and Control 1:179-191, 1990.
8. Gyorfi, T. and Herlyn, M. Melanocyte and melanoma cell lines. In: R. J. Hay, J. G. Park and A. Gazdar (eds.), Atlas of Human Tumor Cell Lines. P. 413, Academic Press, Inc., 1994.
Cell line |
BRAF |
n-ras |
k-ras |
P53 |
WM75 |
V599E |
WT |
WT |
WT |
WM98-1 |
NT |
NT |
NT |
NT |
WM115 |
V599D |
WT |
WT |
WT |
WM278 |
V599E |
WT |
WT |
WT |
WM740V |
NT |
NT |
NT |
NT |
WM793B |
V599E |
WT |
WT |
NT |
WM853-2 |
NT |
NT |
NT |
NT |
WM902B |
V599E |
WT |
WT |
NT |
WM983A |
V599E |
WT |
WT |
NT |
WM1341D |
V599R |
WT |
NT |
NT |
WM1361A |
WT |
61 |
WT |
NT |
WM3268V |
V599E |