JOIN US IN SAVING LIVES
Please make a 2013 year-end donation and help us cure cancer and other deadly diseases.Donate >
Resistance to signaling inhibitors
We can develop over three to six months resistance to any kinase signaling inhibitors. The mechanisms are several fold and may change from tumor to tumor.
Villanueva, J, Vultur, A., Lee, J.T., Somasundaram, R., Fukunaga-Kalabis, M., Cipolla, A.K., Wubenhorst, B., Xu, X., Gimotty, P.A., Kee, D., Santiago-Walker, A.E., Letrero, R., D’Andrea, K., Pushparajan, A., Hayden, J.E., Dahlman, K., Laquerre, S., McArthur, G., Sosman, J., Nathanson, K.L., Herlyn, M.Acquired resistance to BRAF inhibitors mediated by an A/B/C RAF kinase switch in melanoma can be overcome by co-targeting MEK and IGF-1R/PI3K. Cancer Cell 18: 683-695, 2010. PMID21156289.
Villanueva, J., Vultur, A., Herlyn, M.: Resistance to BRAF inhibitors: Unraveling mechanisms and future treatment options. Cancer Res 71: 7137-7140, 2011. PMID22131348
The microscope in the image belonged to William E. Horner, M.D., a collaborator with Caspar Wistar, M.D., in the early 1800s.
Dr. Horner, a lecturer at the University of Pennsylvania, was a pioneer of the use of microscopes in anatomical and medical research. He authored Special Anatomy and Histology, a seminal text on the subject.