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Resistance Therapy

Resistance to signaling inhibitors

We can develop over three to six months resistance to any kinase signaling inhibitors. The mechanisms are several fold and may change from tumor to tumor.

 

Related References:

Villanueva, J, Vultur, A., Lee, J.T., Somasundaram, R., Fukunaga-Kalabis, M., Cipolla, A.K., Wubenhorst, B., Xu, X., Gimotty, P.A., Kee, D., Santiago-Walker, A.E., Letrero, R., D’Andrea, K., Pushparajan, A., Hayden, J.E., Dahlman, K., Laquerre, S., McArthur, G., Sosman, J., Nathanson, K.L., Herlyn, M.Acquired resistance to BRAF inhibitors mediated by an A/B/C RAF kinase switch in melanoma can be overcome by co-targeting MEK and IGF-1R/PI3K. Cancer Cell 18: 683-695, 2010. PMID21156289.

Villanueva, J., Vultur, A., Herlyn, M.: Resistance to BRAF inhibitors: Unraveling mechanisms and future treatment options. Cancer Res 71: 7137-7140, 2011. PMID22131348