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Center for Systems and Computational Biology

The Wistar Institute

3601 Spruce Street

Philadelphia, PA 19104-4268

 

Office: 215-495-6903

Fax: 215-495-6848

Collaborators

Louise C. Showe, Ph.D.

Professor, Molecular and Cellular Oncogenesis Program

The research team led by Louise C. Showe, Ph.D., is using DNA microarray technology to better understand a number of diseases and conditions in which changes in the activity of multiple genes are involved. Among these are a type of cancer known as cutaneous T-cell lymphoma, septic shock, multiple sclerosis, and even obesity. Microarrays allow the scientists to survey and compare the simultaneous activity of thousands of genes in normal and diseased tissues. The ultimate aim is to improve diagnostic techniques and identify promising new targets for therapy.

Kazuko Nishikura, Ph.D. 

Professor, Gene Expression and Regulation Program

RNA carries the genetic instructions of DNA to the cellular machinery responsible for synthesizing the proteins of the body. The Nishikura laboratory is exploring the phenomenon of RNA editing, a process by which a single gene can produce a number of closely related but distinct proteins. Recent studies suggest that disruptions in RNA editing may play a role in certain forms of depression and schizophrenia.

Tim Huang, Ph.D.

Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University

Dissecting epigenetic networks in the cancer genome.

George Calin, Ph.D.

Associate Professor, University of Texas, MD Anderson Cancer Centre in Houston, TX

The roles of microRNAs and other non-coding RNAs in cancer initiation and progression as well as the mechanisms of cancer predisposition.