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The broad research interest of my laboratory is to identify new molecular targets responsible for interaction between tumor cells and their microenvironment that promote tumor growth and chemoresistance and validate these targets in preclinical studies. In this context, we are focusing on the role of receptor/transcriptional regulator Notch in the biology of multiple myeloma, a cancer of plasma cells. Another research interest of my laboratory is to understand the role of myeloid derived suppressor cells in multiple myeloma and determine molecular mechanisms that mediate the effects of these cells on myeloma growth and chemoresistance.
The microscope in the image belonged to William E. Horner, M.D., a collaborator with Caspar Wistar, M.D., in the early 1800s.
Dr. Horner, a lecturer at the University of Pennsylvania, was a pioneer of the use of microscopes in anatomical and medical research. He authored Special Anatomy and Histology, a seminal text on the subject.