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The Wistar Institute

3601 Spruce Street

Philadelphia, PA 19104

Summary

The broad research interest of my laboratory is to identify new molecular targets responsible for interaction between tumor cells and their microenvironment that promote tumor growth and chemoresistance and validate these targets in preclinical studies. In this context, we are focusing on the role of receptor/transcriptional regulator Notch in the biology of multiple myeloma, a cancer of plasma cells. Another research interest of my laboratory is to understand the role of myeloid derived suppressor cells in multiple myeloma and determine molecular mechanisms that mediate the effects of these cells on myeloma growth and chemoresistance.