Our Science

Hui Hu, Ph.D.

Hui Hu, Ph.D.

  • Associate Professor, Tumor Microenvironment and Metastasis Program
  • Member, Vaccine Center
  • 215-495-6820, Office
Summary

Research in the Hu laboratory focuses on transcriptional regulation of cell development and function in the immune system. One goal of the laboratory is to identify novel regulatory genes/networks of T cell quiescence and determine their roles in T cell homeostasis, tolerance, and immune responses. Knowledge obtained from these studies will help design new therapeutic strategies that would manipulate T cell quiescence/activation for the treatment of autoimmune and infectious diseases and cancer. Another direction of the research in the Hu laboratory is to understand the hierarchical regulatory networks of key transcription factors that are engaged in hematopoiesis/lymphopoiesis. 

Hu joined The Wistar Institute faculty in 2007. Hu was formerly an instructor in the Department of Pediatrics at Harvard’s Children’s Hospital, Boston, and a postdoctoral associate at the CBR Institute for Biomedical Research at Harvard Medical School. Prior to joining Harvard in 2002, he served as a postdoctoral associate at the Center for Cancer Research at MIT and as a postdoctoral fellow at the Trudeau Institute. Hu received his doctorate from Stockholm University, Stockholm, Sweden.

Selected Publications

1 - Feng, X., Wang, H., Takada, H., Day, T., Willen, J. and Hu, H. (2011) Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nature Immunology. 12, 544-550 (see News and Views in Nat. Immunol. 12, 522-524; featured as Article of the month).

2 - Feng, X., Ippolito, G. C., Tian, L., Karla, W., Oh, S., Sambandam, A., Willen, J., Bunte, R. M., Maika, S. D., Harriss, J.V., Caton, A. J., Bhandoola, A., Tucker, P. W., and Hu, H. (2010) Foxp1 is an essential transcriptional regulator for the generation of quiescent naïve T cells during thymocyte development. Blood. 115, 510-518.

3 - Hu, H., Djuretic, I., Sundrud, M.S. and Rao, A. (2007) Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT. Trends. Immunol. 28, 329-332.

4 - Hu, H., Wang, B., Borde, M., Maika, S., Nardone, J., Allred, L., Tucker, P.W. and Rao, A (2006) Foxp1 is an essential transcriptional regulator of B cell development. Nature Immunology. 7, 819-826 (see News and Views in Nat. Immunol. 7, 793-794).

5 - Hu, H., Huston, G., Duso, D., Lepak, N., Roman, E. and Swain, S.L. (2001) CD4 T cell effectors can become memory cells with high efficiency and without division. Nature Immunology. 2, 705-710.

6 - Swain, S. L., Hu, H. and Huston, G.  (1999) Class II independent generation of CD4 memory T cells from effectors. Science. 286, 1381-1383.