Libraries

The laboratory has a number of chemical compound libraries including:

NIH Clinical Collection

The NIH Clinical Collection (NCC) is a plated array of approximately 450 small molecules that have a history of use in human clinical trials. The collection was assembled by the National Institutes of Health (NIH) through the Molecular Roadmap Initiative as part of its mission to enable the use of compound screens in biomedical research.

The Spectrum Collection (from MicroSource)

This is a collection of 2000 compounds.  About half of the collection are known bioactive agents, permitting the evaluation of hundreds of marketed drugs and biochemical standards.  The other half of the collection are pure natural products and their derivatives. The collection includes simple and complex oxygen heterocycles, alkaloids, sequiterpenes, diterpenes, pentercyclic triterpenes, sterols, and many other diverse representatives.

The Maybridge “HitFinder” Library

The HitFinder™ Collection comprises 14,400 premier compounds representing the drug-like diversity of the Maybridge Screening Collection, using a clustering algorithm based on standard Daylight Fingerprints and Tanimoto similarity. All screening compounds fit Lipinski guidelines for "Drug-likeness" (logP <=5, H-bond acceptors <=10, H-bond donors <=5, Molecular Weight <= 500), and all have purity greater than 90%. Compounds have been selected to be non-reactive, ensuring fewer false positives and higher quality results.

ChemDiv

The Discovery Chemistry (DC) Set consists of 30,000 compounds from ChemDiv’s diverse drug-like small molecules.  The Target Specific Chemistry (TS) Set consists of 20,000 compounds of which 8,000 compounds target GPCR, 5,000-kinases, 3,000-Ion Channels, 3,000-NHR, and 1,000-proteases.

Lankenau Chemical Genomics Center (LCGC)

The LCGC library set is composed of ~120,000 unique compounds that pass all Lipinski and drug reactivity filters typically used in pharma to qualify drug-like libraries for high throughput screening (HTS).

The Maybridge RO3 Fragment Library

The Maybridge RO3 Fragment Library is composed of 1500 rule of three compliant (MW<300 Da, cLogP <3, H-bond donors/acceptors<3) chemically diverse fragments with assured solubility.

SelleckChem Bioactive Compound Library

A unique collection of ~1000 bioactive chemical compounds, including FDA approved compounds, annotated inhibitors natural products, and chemotherapeutic agents.  Bioactivity and safety confirmed by preclinical research and clinical trials.

Natural Products Discovery Institute

A set of Natural Product extracts prepared from a variety of microbes and plants.  The samples represent a spectrum of moderate-polarity and polar solvent preparations from liquid fungal fermentations, solid-substrate fungal fermentations, liquid actinomycete fermentations, and a wide variety of plant species selected to cover a maximum number of genera of higher plants.

Molecular Targeted Cancer Therapies

A collection of ~100 molecular targeted cancer therapeutics, representing a broad range of targets (e.g. kinases, epigenetics, chaperones, etc).