The three distinct yet complementary research programs in The Wistar Institute Cancer Center are the Gene Expression and Regulation program, and the Molecular and Cellular Oncogenesis program, and the Tumor Microenvironment and Metastasis program.
Aim: To explore cancer and other diseases at the level of individual genes and gene systems, including investigations of the molecular mechanisms of gene regulation.
Aim: To understand cell signaling in tumorigenesis, metastasis and cell differentiation and to use biological and systems biological approaches to develop new strategies for cancer diagnosis and therapy.
Aim: To understand how stromal, inflammatory and endothelial components of the tumor mass play a pivotal role in disease maintenance, progression and dissemination.
Aim: To investigate the mechanisms regulating immune responses in cancer and their potential therapeutic manipulation.