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Monoclonal Antibodies that
Bind to Nerve Growth Factor Receptor (NGFR)(ME20.4
and ME82.11)
Inventor: Meenhard Herlyn
Tech ID: HM-07RR
Description:
Nerve growth factor is important for regulation of development of
sympathetic and sensory neurons and other neural crest-derived cell
types. MAbs ME20.4 and ME82.11 bind to the low affinity NGFR of
human origin. Using these MAbs, we have carefully defined the biochemical
nature of the NGF receptor and its distribution among normal and
transformed neural crest tissues.
Origin:
MAb ME20.4 was prepared by using WM245 melanoma cells as immunogen
in BALB/c mice. ME82.11 was derived by immunizing mice with WM 115
melanoma cells. Spleen cells were fused with mouse myeloma P3x63Ag8.653.
Isotype:
IgG1
Application:
Identification of NGFR+ cells.
Keywords:
monoclonal antibodies, human nerve growth factor receptor, immunodiagnostics,
cell selection, melanomas, gliomas, neuroblastomas
Reference:
Ross, et al., Characterization of nerve
growth factor receptor inneural crest
tumors using monoclonal antibodies, Proc.
Natl. Acad. Sci. 81: 6681-6685, 1984
Contact:
Meryle J. Melnicoff, Ph.D.
Director, Business Development The Wistar Institute
Phone: (215) 898-0049
melnicoff@wistar.org
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