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ANTI-p16 Monoclonal Antibodies
(p16-25; p16-D8-1; p16-D8-2; p16-D8-3; p16-D8-4)
Inventors:
Meenhard
Herlyn and Kapaettu Satyamoorthy
Tech
ID: HM-06RR
Description:
p16 (INK4, MTS1, CDK4IN, CDKN2) is a major tumor suppressor gene,
which is found deleted or mutated in many types of human cancers.
Thus, presence or absence of p16 protein in human cancer cells is
an important diagnostic criterion.
Origin:
BALB/c mice were immunized with the human recombinant p16 fusion
protein from E.coli. Fusion of spleen cells of immunized mice was
done with the non-secreting mouse myeloma cell line P3x63Ag8.SP2/0.
All antibodies bind specifically to p16 in its
recombinant or native form by ELISA, Western blotting. They also
bind to p16 expressed by melanomas and nevi in situ.
Isotype:
p16-25 (IgG1); p16-D8-1 (IgG1); p16-D8-2 (IgG1); p16-D8-3 (IgG1);
p16-D8-4 (IgG1)
Application:
Research, histochemistry, Western blotting
Keywords:
Diagnosis of suppressor gene.
Contact:
Meryle J. Melnicoff, Ph.D.
Director, Business Development The Wistar Institute
Phone: (215) 898-0049
melnicoff@wistar.org
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