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Anti-Human
Tenascin Monoclonal Antibodies 300-1,
300-3, 300-2, 302-1, 302-9
Inventor:
Meenhard Herlyn
Tech ID:
HM09RR
Description:
Origin: MAbs 300-1, 300-3, 300-2, 302-1, 302-9 were derived
by immunizing BALB/c mice with a high molecular weight fraction
of culture supernatants of melanoma cells. Fusion was done with
a non-secreting variance of myeloma P3x63Ag8.653.
Tenascin is a large glycoprotein of the extracellular
matrix and can be found in adult tissues during wound healing and
tumorigenesis. These MAbs define four different epitopes on the
human tenascin molecule. Tenascin levels are increased in sera of
patients with advanced melanoma, and melanoma cells in culture secrete
tenascin constitutively but do not attach to it. Glioma cells are
also major producers of tenascin. Radiolabeled anti-tenascin antibodies
can be used for radiolocalization and therapy of gliomas.
Isotype:
IgG1
Keywords:
Industrial Relevance: Diagnosis of tenascin in serum; radiolocalization
and therapy of gliomas
Applications:
Immunohistochemistry, western blot, serum
detection.
Contact:
Meryle J. Melnicoff, Ph.D.
Director, Business Development The Wistar Institute
Phone: (215) 898-0049
melnicoff@wistar.org
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