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Monoclonal
Antibodies Against Human Chondroitin Sulfate
Proteoglycan (ME31.3; ME95-45)
Inventor:
Meenhard
Herlyn
Tech
ID: HM03RR
Description:
Origin: MAbs ME31.3 and ME95-45 were derived by fusion with P3X63Ag8.653
after immunization of mice with melanoma cells.
Immunoprecipitates a >260 Kd glycoprotein that
is expressed by human melanoma cells. MAb 95-45 detects an antigen
present in sera of patients with advanced metastatic melanoma but
absent in sera of patients with other malignancies or of healthy
subjects.
Reactivity: MAbs
ME31.3 and ME95-45 have a high level of reactivity with melanoma
cells. They react with ocular melanoma and with nevus cells in culture.
Isotype: IgG1
Keywords:
Applications:
Immunohistochemistry, immunoprecipitation.
Contact:
Meryle J. Melnicoff, Ph.D.
Director, Business Development The Wistar Institute
Phone: (215) 898-0049
melnicoff@wistar.org
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