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Monoclonal Antibodies
For Influenza Research
Inventor: Walter
Gerhard
Tech
ID: GW-01RR
Characteristics:
These antibodies specifically bind to
the identified antigens on influenza viruses.
All of the antibodies are useful for ELISA
and some of the antibodies are also useful
for Western blot. The specificity of the
various antibodies that have been characterized
is as shown:
|
Antibody |
Isotype |
Specificity |
Reference |
|
|
| H36-4-5.2 |
IgG2a/k |
H1 (PR8) |
2, 3, 5,
7-8, 11 |
| Many Others |
Various |
H1 (PR8) |
2, 3, 5,
7-8, 11 |
|
|
| NA-112-S2.4 |
IgG2a/k |
N1 (PR8) |
9 |
|
|
| H15-B9-22 |
IgG2a/k |
H1 (WSN) |
6 |
| Few others |
Various |
H1 (WSN) |
6 |
|
|
| CM1-4 |
IgG2b/k |
H1 (110-120) |
|
| |
|
Reacts with
1934-1957 strains |
|
| |
|
Later strains
nd |
|
|
|
| H14-A21-1R1 |
G1/k |
H3 (Aichi/68,
Mem/72, others nd) |
4 |
| Few others |
Various |
H3 (Aichi/68) |
|
|
|
| M1-1C6-5 |
G1/k |
M1 |
1 |
| H18-S12-3 |
G2a/k |
M1 |
1 |
| Few others |
G1/k |
M1 |
1 |
|
|
| M2-56 |
G2a/k |
M2 |
10 |
| Few others |
G2a/k |
M2 |
10 |
|
|
| H16-L10-4R5 |
G2a/k |
NP (x-reacts
with PR8 and Aichi) |
1 |
| H19-S24-4 |
G2a/k |
NP (x-reacts
with early H1N1 strains) |
1 |
| Many others
(less characterized) |
various |
NP |
|
|
|
| 1.1B8 |
G2a/k |
H (B/Lee) |
|
| Few others |
G2a/k |
H (B/Lee) |
|
References:
1. Yewdell,
J.W., Frank, E., and Gerhard, W. J. Immunol.
126: 1814-1819, 1981.
2. Gerhard, W., Yewdell,
J., Frankel, M., and Webster, R.G. Nature
290: 713-717, 1981.
3. Caton, A.J., Brownlee,
G.G., Yewdell, J.W., and Gerhard, W. Cell
31: 417-427, 1982.
4. Jackson, D.C., Murray,
J.M., White, D.O., and Gerhard, W. Infec.
and Immunity 37: 912-918, 1982
5. Staudt, L.M. and
Gerhard, W. J. Exp. Med. 157: 687-704,
1983
6. Nohinek et al. Virology
143: 651-656, 1985
7. Kavaler J et al.
J. Immunol. 145: 2312-2321, 1990.
8. Caton, A.J., Stark,
S.E., Kavaler, J., Staudt, L.M., Schwartz,
D., and Gerhard, W. J. Immunol. 147: 1675-1687,
1991.
9. Mozdzanowska et al.
Virology 254: 138-146, 1999.
10. Zhang, M., Zharikova,
D., Mozdzanowska, K., Otvos, L., and Gerhard,
W. Mol. Immunol. 43: 2195-2206, 2006.
11. Mozdzanowska,
K., Feng, J., Eld, M., Zharikova, D.,
Gerhard, W. Virology (in press), 2006.
Licensing
Opportunity: These
antibodies are available for non-exclusive
license for research or diagnostic use.
Keywords:
Influenza, Research
Tools, Monoclonal Antibodies
Contact:
Meryle J. Melnicoff, Ph.D.
Director, Business Development The Wistar Institute
Phone: (215) 898-0049
melnicoff@wistar.org
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