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Monoclonal Antibodies to ADAR
Inventor:
Kazuko Nishikura
Tech ID:
NK9480, NK0701RR, NK0702RR, NK0703RR
Description:Adenosine Deaminase Acting on RNA (ADAR) is a member of a gene family that is involved in site-selective RNA editing that changes adenosine residues to inosine. Three vertebrate ADAR gene family members, ADAR1, ADAR2,and ADAR3, have been identified. ADAR1 and ADAR2 form a stable enzymatically active homodimer complex and ADAR3 is a monomeric, enzymatically inactive form.
anti-ADAR1 (made against dsRNA binding domain region)
Clone |
Isotype |
Tested In |
|
|
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15.8.6 |
IgG |
Western Blot & Immunohistochemistry |
References: Q. Wang et al. (2000) Requirement of the RNA Editing Deaminase ADAR1 Gene for Embryonic Erythropoiesis, Science Vol. 290, 1765-1768
Dan-Sung C. Cho et al. (2003) Requirement of Dimerization for RNA Editing Activity of Adenosine Deaminases Acting on RNA, The Journal of Biological Chemistry Vol. 278 No. 19, 17093-17102
anti-ADAR2 (made against N-terminal region)
Clone |
Isotype |
Tested In |
|
|
|
1.3.1 |
IgG |
Western Blot & Immunohistochemistry |
References: Dan-Sung C. Cho et al. (2003) Requirement of Dimerization for RNA Editing Activity of Adenosine Deaminases Acting on RNA, The Journal of Biological Chemistry Vol. 278 No. 19, 17093-17102
anti-ADAR3 (made against N-terminal region)
Clone |
Isotype |
Tested In |
|
|
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3.591 |
IgG |
Western Blot |
References: Chun-Xia Chen et al. (2000) A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains, RNA Vol. 6, 755-767
Licensing
Opportunity: These antibodies are available for non-exclusive license for research use.
Key Words:
ADAR, adenosine deaminase, RNA Editing
Contact:
Meryle J. Melnicoff, Ph.D.
Director, Business Development
The Wistar Institute
Phone: (215) 898-0049
melnicoff@wistar.org
Last updated: Jan-07
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