By Inventor

  • RNA Editing Enzyme and Methods of Use Thereof 

    The ADAR (adenosine deaminase that acts on RNA) enzyme, previously known as DRADA, is involved in the RNA editing of glutamate-gated ion channels and the serotonin-2C receptor. This novel enzyme is implicated in central nervous system disorders characterized by abnormal neuronal transmission and intracellular signaling in mammalian brain such as stroke, schizophrenia, depression, and substance abuse.

  • Monoclonal Antibodies to ADAR 

    Adenosine Deaminase Acting on RNA (ADAR) is a member of a gene family that is involved in site-selective RNA editing that changes adenosine residues to inosine.  Three vertebrate ADAR gene family members, ADAR1, ADAR2,and ADAR3, have been identified.  ADAR1 and ADAR2 form a stable enzymatically active homodimer complex and ADAR3is a monomeric, enzymatically inactive form.

    anti-ADAR1 (made against dsRNA binding domain region)

    Clone

    Isotype

    Tested In

     

     

     

    15.8.6

    IgG

    Western Blot & Immunohistochemistry

    References:    Q. Wang et al.  (2000)  Requirement of the RNA Editing Deaminase ADAR1 Gene for Embryonic Erythropoiesis, Science Vol. 290, 1765-1768

                            Dan-Sung C. Cho et al. (2003)  Requirement of Dimerization for RNA Editing Activity of Adenosine Deaminases Acting on RNA, The Journal of Biological Chemistry Vol. 278 No. 19, 17093-17102

    anti-ADAR2 (made against N-terminal region)

    Clone

    Isotype

    Tested In

     

     

     

    1.3.1

    IgG

    Western Blot & Immunohistochemistry

    References:    Dan-Sung C. Cho et al. (2003)  Requirement of Dimerization for RNA Editing Activity of Adenosine Deaminases Acting on RNA, The Journal of Biological Chemistry Vol. 278 No. 19, 17093-17102

    anti-ADAR3 (made against N-terminal region)

    Clone

    Isotype

    Tested In

     

     

     

    3.591

    IgG

    Western Blot

    References:    Chun-Xia Chen et al.  (2000)  A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains, RNA Vol. 6, 755-767