Vultur A, Herlyn M. Cracking the system: melanoma complexity demands new therapeutic approaches. Pigment Cell Melanoma Res. 2009 Feb;22(1):4-5. Epub 2008 Dec 1. No abstract available. PMID: 19054340 [PubMed - in process] (PDF)
Kalabis J, Oyama K, Okawa T, Nakagawa H, Michaylira CZ, Stairs DB, Figueiredo JL, Mahmood U, Diehl JA, Herlyn M, Rustgi AK. A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. J Clin Invest. 2008 Dec;118(12):3860-9. doi: 10.1172/JCI35012. Epub 2008 Nov 6. (PDF)
Harada H, Nakagawa H, Takaoka M, Lee J, Herlyn M, Diehl JA, Rustgi AK. Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes. Cell Cycle. 2008 Nov 15;7(22):3534-8. Epub 2008 Nov 18. (PDF)
Villanueva J, Herlyn M. Melanoma and the tumor microenvironment. Curr Oncol Rep. 2008 Sep;10(5):439-46. Review. (PDF)
Kalabis, J., Li, G., Fukunaga-Kalabis, M., Rustgi, A., Herlyn, M: Endothelin-3 stimulates survival of goblet cells in organotypic cultures of human colonic epithelium. Am. J Physiol - GI Liver Physiol., Oct. 2, 2008, [Epub ahead of print]. PMID18832450 (PDF)
Smalley, K.S.M., Contractor, R., Nguyen, T.K., Xiao, M., Medinca, A., Edwards, R., Muthusamy, V., King, A.J., Flaherty, K.T., Bosenberg, M., Herlyn, M., Nathanson, K.L.: Identification of a novel sub-group of melanomas with kit/cyclin-dependent kinase-4 overexpression. Cancer Res. 68: 5743-5752, 2008. PMID1863262 (PDF)
Smalley, K.S.M., Lioni, M., Palma, M.D., Xiao, M., Desai, B., Eghazi, S., Hansson, J., W, H., King, A.J., Flaherty, K.T., Herlyn, M., Nathanson, K.L.: Cyclin D1 mediates BRAF inhibitor resistance in a sub-set of BRAF-V600E mutated melanomas. Molec. Can. Ther: 7: 2876-2883, 2008. PMID18790768 (PDF)
Lioni, M., Noma, K, Snyder, A., Rustgi, A., Diehl, J.A. , Herlyn, M., Smalley, K.: Bortezomib-induced cellular stress via the p38 MAPK pathway leads to a DNA damage response and apoptosis in esophageal squamous cell carcinoma cells. Molec. Cancer Ther:7: 2866-2875, 2008. PMID18790767 (PDF)
Smalley, K.S.M., Xiao, M., Villanueva, J., Nguyen, T.K., Flaherty, K.T., Letrero, R., Nathanson, K.L., Herlyn, M.: CRAF inhibition induces Bcl-2 dependent apoptosis in melanomas with non V600E BRAF mutations. Oncogene, [Epub ahead of print] Sept. 15, 2008. PMID18794803 (PDF)
Zabierowski, S.E., and Herlyn, M.: Melanoma stem cells: the dark seed of melanoma. J Clin. Oncol.: 26:2890-2894, 2008, PMID 18539969 (PDF)
Fukunaga-Kalabis, M., et al., Downregulation of CCN3 expression as a potential mechanism for melanoma progression. Oncogene, 2008. 27(18): p. 2552-60. (PDF)
Noma, K., et al., The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology, 2008. 134(7): p. 1981-93. (PDF)
Maksimoska, J., Williams, D.S., Atilla-Gokcumen, G.E., Smalley, K.S.M., Carroll, P. J., Webster, R. D., Filippakopoulos, P., Knapp, S., Herlyn, M., Meggers, E.: Isostructural ruthenium and osmium complexes display highly similar bioactivities. Chemistry 14: 4816-4822, 2008. (PDF)
Alfano, R.W., Leppla, S.H., Liu, S., Bugge, T.H., Herlyn, M. Smalley, K.S., Duesberg, N.S., Houghton, A., Frankel, A.E.: Cytotoxicity of the engineered matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells. Molec. Cancer Therap. 8: 1218-1226, 2008. (PDF)
Xie, P., Williams, D.S., Atilla Gokumen, G.E., Milk, L., Xiao, M., smalley, K.S., Herlyn, M., Meggers, E., Marmorstein, R.: Structure- based design of an organoruthenium phosphotidyl-inositol-3-kinase inhibitor revieals a switch governing lipid kinase potency and selectivity. ACS Chem. Biol. 3: 305-316, 2008. (PDF)
Zabierowski press., S.E., and Herlyn, M.: Melanoma stem cells: the dark seed of melanoma. J Clin. Oncol., 28(27): 2890-2891, 2008. (PDF)
Basu, D., Herlyn, M.: Salmonella Typhimurium and a novel RNA interference vector for cancer gene therapy. Cancer Biol. Therap. 7: 151-152. 2008. (PDF)
Lee. J. T., Brafford, P., Herlyn, M.: Unreveling the mysteries of IGF-1 signaling in melanoma. J. Invest. Dermatol. 128: 1358-1360, 2008. (PDF)
Zabierowski, SE, Herlyn, M. Learning the ABC’s of Melanoma-Initaiting Cells. Cancer Cell. Mar; 13(3): 185-187, 2008. PDF
Haass, N.K., Sproesser, K., Nguyen, T.K., Contractor, R., Medina, C. A., Nathanson, K. L., Herlyn, M., Smalley, K. S. M.: The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel. Clin Cancer Res. 14(1), 230-239, 2008. (PDF)
Smalley, KS, Lioni, M, Noma, K, Haass, N.K., Herlyn, M. In vitro three-dimentional tumor microenvironment models for anticancer drug discovery. Expert Opinion Drug Discov. 3, 1-20, 2008. (PDF)
Han, M.-J., Herlyn, M., Fisher, A.B. Speicher, D. W.: Microscale solution IEF combined with 2-D DIGE substantially enhances analysis depth of complex proteomes such as mammalian cell and tissue extracts. Electrophoresis, 29: 695-705, 2008. (PDF)
Gordon, A., Kozin, E.D., Keswani, S.G., Vaikunth, S.S., Katz, A.B., Zoltick, P.W., Favata, M., Radu, A.P., Soslowsky, L.J., Herlyn, M., Crombleholme, T.M.: Permissive environment in postnatal wounds by adenoviral-mediated overexpression of the anti-inflammatroy cytokine interleukin-10 prevents scar formation. Wound Repair Regen. 16(1): 70-79, 2008. (PDF)
Sigalotti L, Covre A, Zabierowski, S, Himes B, Colizzi F, Natali PG, Herlyn M, Maio M. Cancer testis antigens in human melanoma stem cells; Expression, distribution, and methylation status. J Cell Physiol. May: 215(2): 287-291, 2008. PDF
Lin WM, Baker, AC, Beroukhim R, Winckler W, Feng W, Marmion JM, Laine E, Greulich H, Tseng H, Gates C, Hodi FS, Dranoff G, Sellers WR, Thomas RK, Meyerson M, Golub TR, Dummer R, Herlyn M, Getz G, Garraway LA. Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res. 68(3): 664-673, 2008. PDF
Tsai, J., Lee, J.T., Wang, W. Zhang, J., Cho, H., Mamo, S., Bremer, R., Gilette, S., Kong, J., Haass, N.K., Sproesser, K., Li, L., Smalley, K.S.M., Fong, D., Zhu, Y-L., Marimuthu, A., Nguyen, H., Lam, B., Liu, J., Cheung, I., Rice, J., Suzuki, Y., Luu, C., Settachatgul, C., Shellooe, R., Cantwell, J., Kim, S-H, Schlessinger, J., Zhang, K.Y.J., West, B., Powell, B., Habets, G., Zhang, C., Ibrahim, P.N. Hirth, P., Artis, D.R., Herlyn, M., Bollag, G. : Discovery of a novel selective inhibitor of oncogenic B-Raf kinase with potent anti-melanoma activity. Proc. Nat. Acad. Sc. (USA). Feb 26; 105(8); 3041-3046, 2008. PDF
Zecchini, S., Bianchi, M., Colombo, N., Fasani, R., Goisis, G., Casadio, C., Viale, G., Liu, J., Herlyn, M., Godwin, A., Nuciforo, P., Cavallaro, U.: the divergent role of Li in normal and transformed ovarian surface epithelial cells. Implications for ovarian carcinoma progression. Cancer Res. Feb 15; 68(4): 1110-1118, 2008. PDF