Non-canonical functions of cyclins

Non-canonical functions of cyclins

Non-canonical functions of cyclins

Monday, May 21, 2012 - 10:00am

Joseph N. Grossman, M.D. Auditorium
The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104

Richard G. Pestell, M.D., Ph.D. will present this lecture.
This event is free and open to the public. For more information, call 215-898-3944.

Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular substrates. Although their classical role in cell cycle progression and tumorigenesis has been well characterized, a variety of new functions have been identified, including the induction of cellular migration and invasion, enhancement of angiogenesis, inhibition of mitochondrial metabolism, regulation of transcription factor signaling via a DNA bound form, the induction of chromosomal instability, enhancement of DNA damage sensing and DNA damage repair, and feedback governing expression of the non-coding genome. Many of the new functions involve kinase-independent activities. This review describes the new functions of the cyclins, with a focus on cyclin D1.