Publications: 2008

Maksimoska, J., Williams, D.S., Atilla-Gokcumen, G.E., Smalley,  K.S.M., Carroll, P. J., Webster, R. D., Filippakopoulos, P., Knapp,  S., Herlyn, M., Meggers, E.: Isostructural ruthenium and osmium  complexes display highly similar bioactivities. Chemistry 14:  4816-4822, 2008.   (PDF)

Alfano, R.W., Leppla, S.H., Liu, S., Bugge, T.H., Herlyn, M. Smalley, K.S., Duesberg, N.S., Houghton, A., Frankel, A.E.: Cytotoxicity of the engineered matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells. Molec. Cancer Therap. 8: 1218-1226, 2008.   (PDF)

Xie, P., Williams, D.S., Atilla Gokumen, G.E., Milk, L., Xiao, M., smalley, K.S., Herlyn, M., Meggers, E., Marmorstein, R.: Structure- based design of an organoruthenium phosphotidyl-inositol-3-kinase inhibitor revieals a switch governing lipid kinase potency and selectivity. ACS Chem. Biol. 3: 305-316, 2008.   (PDF)

Zabierowski press., S.E., and Herlyn, M.: Melanoma stem cells: the dark seed of melanoma. J Clin. Oncol., 28(27):  2890-2891, 2008.   (PDF)

Basu, D., Herlyn, M.: Salmonella Typhimurium and a novel RNA interference vector for cancer gene therapy. Cancer Biol. Therap. 7: 151-152. 2008.   (PDF)

Lee. J. T., Brafford, P., Herlyn, M.: Unreveling the mysteries of IGF-1 signaling in melanoma. J. Invest. Dermatol. 128: 1358-1360, 2008.   (PDF)

Zabierowski, SE, Herlyn, M. Learning the ABC’s of Melanoma-Initaiting Cells. Cancer Cell. Mar; 13(3): 185-187, 2008.  PDF

Haas, N.K., Sproesser, K., Nguyen, T.K., Contractor, R., Medina, C. A., Nathanson, K. L., Herlyn, M., Smalley, K. S. M.: The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel. Clin Cancer Res. 14(1), 230-239, 2008. (PDF)

Smalley, KS, Lioni, M, Noma, K, Haass, N.K., Herlyn, M. In vitro three-dimentional tumor microenvironment models for anticancer drug discovery. Expert Opinion Drug Discov. 3, 1-20, 2008.   (PDF)

Han, M.-J., Herlyn, M., Fisher, A.B. Speicher, D. W.: Microscale solution IEF combined with 2-D DIGE substantially enhances analysis depth of complex proteomes such as mammalian cell and tissue extracts. Electrophoresis, 29: 695-705, 2008.   (PDF)
                
Gordon, A., Kozin, E.D., Keswani, S.G., Vaikunth, S.S., Katz, A.B., Zoltick, P.W., Favata, M., Radu, A.P., Soslowsky, L.J., Herlyn, M., Crombleholme, T.M.: Permissive environment in postnatal wounds by adenoviral-mediated overexpression of the anti-inflammatroy cytokine interleukin-10 prevents scar formation. Wound Repair Regen. 16(1): 70-79, 2008.   (PDF)

Sigalotti L, Covre A, Zabierowski, S, Himes B, Colizzi F, Natali PG, Herlyn M, Maio M. Cancer testis antigens in human melanoma stem cells; Expression, distribution, and methylation status.  J Cell Physiol. May: 215(2): 287-291, 2008.   PDF

Lin WM, Baker, AC, Beroukhim R, Winckler W, Feng W, Marmion JM, Laine E, Greulich H, Tseng H, Gates C, Hodi FS, Dranoff G, Sellers WR, Thomas RK, Meyerson M, Golub TR, Dummer R, Herlyn M, Getz G, Garraway LA. Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res. 68(3): 664-673, 2008.  PDF

Tsai, J., Lee, J.T., Wang, W. Zhang, J., Cho, H., Mamo, S., Bremer, R., Gilette, S., Kong, J., Haass, N.K., Sproesser, K., Li, L., Smalley, K.S.M., Fong, D., Zhu, Y-L., Marimuthu, A., Nguyen, H., Lam, B., Liu, J., Cheung, I., Rice, J., Suzuki, Y., Luu, C., Settachatgul, C., Shellooe, R., Cantwell, J., Kim, S-H, Schlessinger, J., Zhang, K.Y.J., West, B., Powell, B., Habets, G., Zhang, C., Ibrahim, P.N. Hirth, P., Artis, D.R., Herlyn, M., Bollag, G. : Discovery of a novel selective inhibitor of oncogenic B-Raf kinase with potent anti-melanoma activity. Proc. Nat. Acad. Sc. (USA). Feb 26; 105(8); 3041-3046, 2008.  PDF

Zecchini, S., Bianchi, M., Colombo, N., Fasani, R., Goisis, G., Casadio, C., Viale, G., Liu, J., Herlyn, M., Godwin, A., Nuciforo, P., Cavallaro, U.: the divergent role of Li in normal and transformed ovarian surface epithelial cells. Implications for ovarian carcinoma progression. Cancer Res. Feb 15; 68(4): 1110-1118, 2008.  PDF