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The Speicher laboratory uses proteomics, computational methods, and biophysical approaches to characterize the roles of normal and mutant proteins in cancers and other human diseases. One approach uses systems biology strategies to better understand tumor progression and resistance to cancer therapeutics. Other major projects include systematic identification of biomarkers to improve clinical management of cancers, identification of cardiotoxicity induced by cancer therapies, identification of ectopic pregnancy biomarkers, defining the role of innate immunity in resistance to HIV infection, and systems-wide analysis of macromolecular structures of the red cell membrane and membrane skeleton.
The microscope in the image belonged to William E. Horner, M.D., a collaborator with Caspar Wistar, M.D., in the early 1800s.
Dr. Horner, a lecturer at the University of Pennsylvania, was a pioneer of the use of microscopes in anatomical and medical research. He authored Special Anatomy and Histology, a seminal text on the subject.