Publications
Article list in PubMed (link)
1 - Mason M, Wanat JJ, Harper S, Schultz DC, Speicher DW, Johnson FB, Skordalakes E. Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance. Structure. 2012 Nov 20. doi:pii: S0969-2126(12)00386-3. 10.1016/j.str.2012.10.012. PMID: 23177925
2 - Skordalakes, E. and Lue, N. F. TERT Structure, Function, and Molecular Mechanisms, in Telomerases: Chemistry, Biology, and Clinical Applications (eds N. F. Lue and C. Autexier), John Wiley & Sons, Inc., (2012), Hoboken, NJ, USA. doi: 10.1002/9781118268667.ch3
3 - Schuller AP, Harkisheimer MJ, Skordalakes E. In vitro Reconstitution of the Active T. castaneum Telomerase. J Vis Exp. 2011 Jul 14;(53). pii: 2799. doi: 10.3791/2799. PubMed PMID: 21775967.
4 - Mason M, Schuller A, Skordalakes E. Telomerase structure function. Curr Opin Struct Biol. 2011 Feb;21(1):92-100. Epub 2010 Dec 17. Review. PubMed PMID: 21168327.
5 - Mitchell MT, Smith JS, Mason M, Harper S, Speicher DW, Johnson FB, Skordalakes E. Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation. Mol Cell Biol. 2010 Nov;30(22):5325-34. Epub 2010 Sep 13. PubMed PMID: 20837709; PubMed Central PMCID: PMC2976383.
6 - Song Y, Willer JR, Scherer PC, Panzer JA, Kugath A, Skordalakes E, Gregg RG, Willer GB, Balice-Gordon RJ. Neural and synaptic defects in slytherin, a zebrafish model for human congenital disorders of glycosylation. PLoS One. 2010 Oct 29;5(10):e13743. PubMed PMID: 21060795; PubMed Central PMCID: PMC2966427.
7 - Mason M, Skordalakes E. Insights into Cdc13 dependent telomere length regulation. Aging (Albany NY). 2010 Oct;2(10):731-4. PubMed PMID: 20975208; PubMed Central PMCID: PMC2993802.
8 - Mitchell M, Gillis A, Futahashi M, Fujiwara H, Skordalakes E. Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA. Nat Struct Mol Biol. 2010 Apr;17(4):513-8. Epub 2010 Mar 28. PubMed PMID: 20357774.
9 - McCray BA, Skordalakes E, Taylor JP. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Hum Mol Genet. 2010 Mar 15;19(6):1033-47. Epub 2009 Dec 22. PubMed PMID: 20028791; PubMed Central PMCID: PMC2830827.
10 - Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS. Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21573-8. Epub 2009 Dec 4. PubMed PMID: 19966225; PubMed Central PMCID: PMC2799888.
11 - Skordalakes E. Telomerase structure paves the way for new cancer therapies. Future Oncol. 2009 Mar;5(2):163-7. Review. PubMed PMID: 19284375.
12 - Skordalakes E. Telomerase and the benefits of healthy living. Lancet Oncol. 2008 Nov;9(11):1023-4. PubMed PMID: 19012852.
13 - Gillis AJ, Schuller AP, Skordalakes E. Structure of the Tribolium castaneum telomerase catalytic subunit TERT. Nature. 2008 Oct 2;455(7213):633-7. Epub 2008 Aug 31. PubMed PMID: 18758444.
14 - Carlson BL, Ballister ER, Skordalakes E, King DS, Breidenbach MA, Gilmore SA, Berger JM, Bertozzi CR. Function and structure of a prokaryotic formylglycine-generating enzyme. J Biol Chem. 2008 Jul 18;283(29):20117-25. Epub 2008 Apr 4. PubMed PMID: 18390551; PubMed Central PMCID: PMC2459300.
15 - Rouda S, Skordalakes E. Structure of the RNA-binding domain of telomerase: implications for RNA recognition and binding. Structure. 2007 Nov;15(11):1403-12. PubMed PMID: 17997966.
16 - Young TA, Skordalakes E, Marqusee S. Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability. J Mol Biol. 2007 May 18;368(5):1438-47. Epub 2007 Mar 6. PubMed PMID: 17397866.
17 - Skordalakes E, Berger JM. Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor. Cell. 2006 Nov 3;127(3):553-64. PubMed PMID: 17081977.
18 - Skordalakes E, Brogan AP, Park BS, Kohn H, Berger JM. Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin. Structure. 2005 Jan;13(1):99-109. PubMed PMID: 15642265.
19 - Daganzo SM, Erzberger JP, Lam WM, Skordalakes E, Zhang R, Franco AA, Brill SJ, Adams PD, Berger JM, Kaufman PD. Structure and function of the conserved core of histone deposition protein Asf1. Curr Biol. 2003 Dec 16;13(24):2148-58. PubMed PMID: 14680630.
20 - Skordalakes E, Berger JM. Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading. Cell. 2003 Jul 11;114(1):135-46. PubMed PMID: 12859904.
21 - Hansen CL, Skordalakes E, Berger JM, Quake SR. A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16531-6. Epub 2002 Dec 16. PubMed PMID: 12486223; PubMed Central PMCID: PMC139178.
22 - Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ. Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate. J Mol Biol. 2001 Aug 17;311(3):549-55. PubMed PMID: 11493008.
23 - Skordalakes E, Elgendy S, Goodwin CA, Green D, Scully MF, Kakkar VV, Freyssinet JM, Dodson G, Deadman JJ. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide. Biochemistry. 1998 Oct 13;37(41):14420-7. PubMed PMID: 9772168.
24 - Deadman JJ, Elgendy S, Goodwin CA, Green D, Baban JA, Patel G, Skordalakes E, Chino N, Claeson G, Kakkar VV, et al. Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin. J Med Chem. 1995 Apr 28;38(9):1511-22. PubMed PMID: 7739010.
