Monoclonal Antibodies: Colon and Rectum
MONOCLONAL ANTIBODIES TO GI TRACT TUMORS
PRODUCED IN OUR LABORATORY
I. Lewis and related antigens
| 1. 1116-NS-19-9 (CO 19-9), IgG1, Sialylated Lea | Koprowski et al. 1979 |
| 2. 129-2-C3-9-11 (CO 29.11), IgG1, Sialylated Lea and Lea (10:1) | Herlyn et al. 1985 |
| 3. 151-6-A7-9-11 (CO 51.4), IgG3, Lea | Blaszczyk et al. 1984a, 1985 |
| 4.a) 143-2-A6-11 (CO 43.1), IgM, Leb b) 130-3-F7-5-9 (CO 30.1), IgG1, Leb |
Blaszczyk et al. 1984a, 1985 Blaszczyk et al. 1984a, 1985 |
| 5. 1116-NS-10-17 (10-17), IgM, Leb and H type 1 | Brockhaus et al. 1981 |
| 6. 151-5-G3-5 (CO 51.3), IgGa3, Lea and Leb (>100:1) | Blaszczyk et al. 1984a, 1985 |
II. X, Y, H and related antigens
| 1.a) WGHS-29-1 (CO 29-1), IgM, X (LNF III) b) D156-45 (CO 56-45), IgM, X |
Brockhaus et al. 1982 Hansson et al. 1983 |
| 2.a) 140-1-C3-3 (BR 40.9), M, X-like b) 261-1-4-7 (61-7), IgG1, X-like |
unpublished |
| 3.a) 363-15-6A (BR 15-6A), IgG2a, Y b) MCF7-55-2 (BR55-21), IgG3, Y/B |
Rodeck et al. 1987 Blaszczyk-Thurin, 1987 |
| 4. BRD8, IgM, H-like | Lindgren et al. 1985 |
III. Blood groups A and B
| 1.a) E115-2 (PA 15-2), IgG3, Bld. grp. B type 2 | Hansson et al. 1983 |
| b) E123-48 (PA 23-48), IgG1. Bld. grp. B type 2 |
Hansson et al. 1983 |
| 2.a) E283-55 (PA 83-52), IgA, Bld. grp. B, types 1 and 2 | Hansson et al. 1983 |
| b) 173-3-45-14 (GA 734), IgA, Bld. grp. B types 1 and 2 | unpublished Reference |
IV. Membrane bound antigens
| 1. 1083-17-1A (CO 171A), IgG2a, 40 Kd | Herlyn et al. 1979 |
| 2. 173-2-35-3-11 (GA 73.3), IgG2a, 33, 35, 38, Kd | Herlyn et al. 1984 |
| 3. WCDK-6-21 (CO 6-21), IgG2a, N.I. | unpublished |
| 4. WGHS-22-9 (CO 22-9), IgG1, N.I. | unpublished |
V. CEA and related proteins
| 1. 1116 NS 3d6.35 (3d6), IgG1, 180 kd | Mitchell et al. 1980, Koprowski et al. 1979 |
| 2. C42032 (CO 2032), IgG2a, 180, 160, 50, 40, Kd | Blaszczyk et al. 1984b |
| 3. 1116 NS 29-10 (CO 29-10), IgG1, 34kD | Koprowski et al. 1979 |
VI. Other antigens
| 1. C41472 (CO 1472), IgG2a, 40 Kd | Herlyn et al. 1982 |
| 2. 144-1-C8-6 (CO 44.1), IgG2a, N.I. | Herlyn et al. 1984 |
| 3. WGHS-9-1 (GA 9-1), IgG1, 25 Kd | unpublished |
| 4. 151-5-E7-9-11 (CO 51.1), IgM, Carbohydrate | unpublished |
| 5. 271-10-19 (271), IgM, N.I. | unpublished |
| 6. 356-9-D7-8 (356-8), IgM, N.I. | unpublished |
References
1. Blaszczyk M, Hansson GC, Karlsson K-A, Larson G, Stromberg N, Thurin J, Herlyn M, Steplewski Z, Koprowski, H: Lewis blood group antigens defined by monoclonal anti-colon carcinoma antibodies. Arch Biochem Biophys 233: 161-168, 1984.
2. Blaszczyk M, Pak KY, Herlyn M, Lindgren J, Pessano S, Steplewski Z: Characterization of gastrointestinal tumor-associated carcinoembryonic antigen-related antigens defined by monoclonal antibodies. Cancer Res 44: 245-253, 1984.
3. Blaszczyk M, Pak KY, Herlyn M, Sears HF, Steplewski Z: Characterization of Lewis antigens in normal colon and gastrointestinal adenocarcinomas. Proc Natl Acad Sci USA 82: 3552-3556, 1985.
4. Blaszczyk-Thurin M, Thurin J, Hindsgaul O, Karlsson K.-A., Larson Y, and Ginsburg U: J Biol Chem. 256: 13223-23226, 1987.
5. Brockhaus M, Magnani JL, Herlyn M, Blaszczyk M, Steplewski Z, Koprowski H, Ginsburg V: Monoclonal antibodies directed against the sugar sequence of lacto-N-fucopentaose III are obtained from mice immunized with human tumors. Arch Biochem Biophys 217: 647-651, 1982.
6. Brockhaus M, Magnani JL, Herlyn M, Blaszczyk M, Steplewski Z, Koprowski H, Ginsburg V: Monoclonal antibodies directed against the sugar sequence of lacto-N-fucopentaose III are obtained from mice immunized with human tumors. Arch Biochem Biophys 217: 647-651, 1982.
7. Hansson GC, Karlsson K-A, Larson G, McKibbin JM, Blaszczyk M, Herlyn M, Steplewski Z, Koprowski H: Mouse monoclonal antibodies against human cancer cell lines with specificities for blood group and related antigens. Characterization by antibody binding to glycosphingolipids in a chromatogram binding assay. J Biol Chem 258: 4091-4097, 1983.
8. Herlyn D, Herlyn M, Ross AH, Ernst C, Atkinson B, Koprowski H: Efficient selection of human tumor growth-inhibiting monoclonal antibodies. J Immunol Meth 73: 157-167, 1984.
9. Herlyn M, Blaszczyk M, Bennicelli J, Sears HF, Ernst C, Ross AH, Koprowski H: Selection of monoclonal antibodies detecting serodiagnostic human tumor markers. J Immunol Meth 80: 107-116, 1985.
10. Herlyn M, Sears HF, Steplewski Z, Koprowski H: Monoclonal antibody detection of a circulating tumor-associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric and pancreatic carcinoma. J Clin Immunol 2: 135-140, 1982.
11. Herlyn M, Steplewski Z, Herlyn D, Koprowski H: Colorectal carcinoma-specific antigen: Detection by means of monoclonal antibodies. Proc Natl Acad Sci USA 76: 1438-1442, 1979.
12. Koprowski H, Steplewski Z, Mitchell K, Herlyn M, Herlyn D, Fuhrer P: Colorectal carcinoma antigens detected by hybridoma antibodies. Somat Cell Genet 5: 957-972, 1979.
13. Hansson GC, Karlsson K-A, Larson G, McKibbin JM, Blaszczyk M, Herlyn M, Steplewski Z, Koprowski H: Mouse monoclonal antibodies against human cancer cell lines with specificities for blood group and related antigens. Characterization by antibody binding to glycosphingolipids in a chromatogram binding assay. J Biol Chem 258: 4091-4097, 1983.
14. Lindgren J, Blaszyck M, Atkinson B, Steplewski Z, and Koprowski H: Hybridoma 4: 37-15, 1985.
15. Mitchell, KF: Cancer Immunol. Immunotherap. 10: 1-5, 1980.
16. Rodeck U, Herlyn M, Leander K, Borlinghaus P, Koprowski H: A mucin containing the X, Y, and H type 2 carbohydrate determinants is shed by carcinoma cells. Hybridoma 6: 389-401, 1987.
