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Monoclonal Antibodies: Colon and Rectum

MONOCLONAL ANTIBODIES TO GI TRACT TUMORS
PRODUCED IN OUR LABORATORY

I. Lewis and related antigens

1. 1116-NS-19-9 (CO 19-9), IgG1, Sialylated Lea Koprowski et al. 1979
2. 129-2-C3-9-11 (CO 29.11), IgG1, Sialylated Lea and Lea (10:1) Herlyn et al. 1985
3. 151-6-A7-9-11 (CO 51.4), IgG3, Lea Blaszczyk et al. 1984a, 1985
4.a) 143-2-A6-11 (CO 43.1), IgM, Leb
   b) 130-3-F7-5-9 (CO 30.1), IgG1, Leb
Blaszczyk et al. 1984a, 1985
Blaszczyk et al. 1984a, 1985
5. 1116-NS-10-17 (10-17), IgM, Leb and H type 1 Brockhaus et al. 1981
6. 151-5-G3-5 (CO 51.3), IgGa3, Lea and Leb (>100:1) Blaszczyk et al. 1984a, 1985

II. X, Y, H and related antigens

1.a) WGHS-29-1 (CO 29-1), IgM, X (LNF III)
   b) D156-45 (CO 56-45), IgM, X
Brockhaus et al. 1982
Hansson et al. 1983
2.a) 140-1-C3-3 (BR 40.9), M, X-like
   b) 261-1-4-7 (61-7), IgG1, X-like

unpublished
unpublished

3.a) 363-15-6A (BR 15-6A), IgG2a, Y
b) MCF7-55-2 (BR55-21), IgG3, Y/B
Rodeck et al. 1987
Blaszczyk-Thurin, 1987
4. BRD8, IgM, H-like Lindgren et al. 1985

III. Blood groups A and B

1.a) E115-2 (PA 15-2), IgG3, Bld. grp. B type 2 Hansson et al. 1983
b) E123-48 (PA 23-48), IgG1. Bld. grp. B type 2

Hansson et al. 1983

2.a) E283-55 (PA 83-52), IgA, Bld. grp. B, types 1 and 2 Hansson et al. 1983
b) 173-3-45-14 (GA 734), IgA, Bld. grp. B types 1 and 2 unpublished Reference

IV. Membrane bound antigens

1. 1083-17-1A (CO 171A), IgG2a, 40 Kd Herlyn et al. 1979
2. 173-2-35-3-11 (GA 73.3), IgG2a, 33, 35, 38, Kd Herlyn et al. 1984
3. WCDK-6-21 (CO 6-21), IgG2a, N.I. unpublished
4. WGHS-22-9 (CO 22-9), IgG1, N.I. unpublished

V. CEA and related proteins

1. 1116 NS 3d6.35 (3d6), IgG1, 180 kd Mitchell et al. 1980,
Koprowski et al. 1979
2. C42032 (CO 2032), IgG2a, 180, 160, 50, 40, Kd Blaszczyk et al. 1984b
3. 1116 NS 29-10 (CO 29-10), IgG1, 34kD Koprowski et al. 1979

VI. Other antigens

1. C41472 (CO 1472), IgG2a, 40 Kd Herlyn et al. 1982
2. 144-1-C8-6 (CO 44.1), IgG2a, N.I. Herlyn et al. 1984
3. WGHS-9-1 (GA 9-1), IgG1, 25 Kd unpublished
4. 151-5-E7-9-11 (CO 51.1), IgM, Carbohydrate unpublished
5. 271-10-19 (271), IgM, N.I. unpublished
6. 356-9-D7-8 (356-8), IgM, N.I. unpublished

References

1. Blaszczyk M, Hansson GC, Karlsson K-A, Larson G, Stromberg N, Thurin J, Herlyn M, Steplewski Z, Koprowski, H: Lewis blood group antigens defined by monoclonal anti-colon carcinoma antibodies. Arch Biochem Biophys 233: 161-168, 1984.

2. Blaszczyk M, Pak KY, Herlyn M, Lindgren J, Pessano S, Steplewski Z: Characterization of gastrointestinal tumor-associated carcinoembryonic antigen-related antigens defined by monoclonal antibodies. Cancer Res 44: 245-253, 1984.

3. Blaszczyk M, Pak KY, Herlyn M, Sears HF, Steplewski Z: Characterization of Lewis antigens in normal colon and gastrointestinal adenocarcinomas. Proc Natl Acad Sci USA 82: 3552-3556, 1985.

4. Blaszczyk-Thurin M, Thurin J, Hindsgaul O, Karlsson K.-A., Larson Y, and Ginsburg U: J Biol Chem. 256: 13223-23226, 1987.

5. Brockhaus M, Magnani JL, Herlyn M, Blaszczyk M, Steplewski Z, Koprowski H, Ginsburg V: Monoclonal antibodies directed against the sugar sequence of lacto-N-fucopentaose III are obtained from mice immunized with human tumors. Arch Biochem Biophys 217: 647-651, 1982.

6. Brockhaus M, Magnani JL, Herlyn M, Blaszczyk M, Steplewski Z, Koprowski H, Ginsburg V: Monoclonal antibodies directed against the sugar sequence of lacto-N-fucopentaose III are obtained from mice immunized with human tumors. Arch Biochem Biophys 217: 647-651, 1982.

7. Hansson GC, Karlsson K-A, Larson G, McKibbin JM, Blaszczyk M, Herlyn M, Steplewski Z, Koprowski H: Mouse monoclonal antibodies against human cancer cell lines with specificities for blood group and related antigens. Characterization by antibody binding to glycosphingolipids in a chromatogram binding assay. J Biol Chem 258: 4091-4097, 1983.

8. Herlyn D, Herlyn M, Ross AH, Ernst C, Atkinson B, Koprowski H: Efficient selection of human tumor growth-inhibiting monoclonal antibodies. J Immunol Meth 73: 157-167, 1984.

9. Herlyn M, Blaszczyk M, Bennicelli J, Sears HF, Ernst C, Ross AH, Koprowski H: Selection of monoclonal antibodies detecting serodiagnostic human tumor markers. J Immunol Meth 80: 107-116, 1985.

10. Herlyn M, Sears HF, Steplewski Z, Koprowski H: Monoclonal antibody detection of a circulating tumor-associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric and pancreatic carcinoma. J Clin Immunol 2: 135-140, 1982.

11. Herlyn M, Steplewski Z, Herlyn D, Koprowski H: Colorectal carcinoma-specific antigen: Detection by means of monoclonal antibodies. Proc Natl Acad Sci USA 76: 1438-1442, 1979.

12. Koprowski H, Steplewski Z, Mitchell K, Herlyn M, Herlyn D, Fuhrer P: Colorectal carcinoma antigens detected by hybridoma antibodies. Somat Cell Genet 5: 957-972, 1979.

13. Hansson GC, Karlsson K-A, Larson G, McKibbin JM, Blaszczyk M, Herlyn M, Steplewski Z, Koprowski H: Mouse monoclonal antibodies against human cancer cell lines with specificities for blood group and related antigens. Characterization by antibody binding to glycosphingolipids in a chromatogram binding assay. J Biol Chem 258: 4091-4097, 1983.

14. Lindgren J, Blaszyck M, Atkinson B, Steplewski Z, and Koprowski H: Hybridoma 4: 37-15, 1985.

15. Mitchell, KF: Cancer Immunol. Immunotherap. 10: 1-5, 1980.

16. Rodeck U, Herlyn M, Leander K, Borlinghaus P, Koprowski H: A mucin containing the X, Y, and H type 2 carbohydrate determinants is shed by carcinoma cells. Hybridoma 6: 389-401, 1987.