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The Wistar Institute

3601 Spruce Street

Philadelphia, PA 19104


Office: 215-495-6835


1 - Gumireddy G, Li A, Kossenkov AV, Sakurai M, Yan J, Li Y, Xu H, Wang J, Zhang P, Zhang L, Showe L, Nishikura K, Huang Q. (2016) The mRNA edited form of GABRA3 suppresses GABRA3 mediated Akt activation and breast cancer metastasis. Nature Communications. (in press)

2 - Wang Z, Deng Z, Dahmane N, Tsai K, Wang P, Williams DR, Kossenkov AV, Showe LC, Zhang R, Huang Q, Conejo-Garcia JR, Lieberman PM. (2016) Telomere repeat RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes. Proceedings of National Academy of Sciences USA (in press)

3 - Yan X, Hu Z, Feng Y, Hu X, Yuan J, Zhao SD, Zhang Y, Yang L, Shan W, He Q, Fan L, Kandalaft LE, Tanyi JL, Li C, Yuan CX, Zhang D, Yuan H, Hua K, Lu, Y, Katsaros D, Huang Q, Montone K, Fan Y, Coukos G, Boyd J, Sood AK, Rebbeck T, Mills GB, Dang CV, Zhang L. (2015) Comprehensive genomic characterization of long non-coding RNAs across human cancers. Cancer Cell 28:529-540.

4 - Gumireddy K, Li A, Chang DH, Liu Q, Kossenkov AV, Yan J, Korst RJ, Nam BT, Xu H, Zhang L, Ganepola GAP, Showe LC, Huang Q. (2015) AKAP4 is a circulating biomarker for non-small cell lung cancer. Oncotarget 6:17637-17647.

5 - Xiao H, Tang K, Liu P, Chen K, Hu J, Zhen J, Xiao W, Yu G, Yao W, Zhou H, Li H, Pan Y, Li A, Ye Z, Wang J, Huang Q, Xu H. (2015) LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma. Oncotarget 6:38005-38015.

6 - Xiao H, Zeng J, Li H, Chen K, Yu G, Hu J, Tang K, Zhou H, Huang, Q, Li A, Li Y, Ye Z, Wang J. (2015) MiR-1 downregulation correlates with poor survival in clear cell renal cell carcinoma where it interferes with cell cycle regulation and metastasis. Oncotarget 6:13201-13215.

7 - Fan S, Liu B, Sun L, Lv X, Lin Z, Chen W, Chen W, Tang Q, Wang Y, Su Y, Jin S, Zhang D, Zhong J, Li Y, Wen B, Zhang Z, Yang P, Zhou B, Liang Q, Yu X, Zhu Y, Hu P, Chu J, Huang W, Feng Y, Peng H, Huang Q, Song E, Li J. (2015) Mitochondrial fission determines cisplatin sensitivity  in tongue squamous cell carcinoma through the BRCA-miR-593-5p-MEF axis. Oncotarget 6:14885-14904. PMID: 25912308.

8 - Yu G, Yao W, Gumireddy K, Li A, Wang J, Xiao W, Chen K, Xiao H, Li H, Tang K, Ye Z, Huang Q*, Xu H*. (2014) Pseudogene PTENP1 functions as a competing endogenous RNA to suppress clear cell renal cell carcinoma progression. Molecular Cancer Therapeutics 13:3086-3097. *corresponding author

9 - Chen K, Yu G, Gumireddy K, Li A, Yao W, Gao L, Chen S, Hao J, Wang J, Huang Q, Ye Z, Xu H. (2015) ZBRK1, a novel tumor suppressor, activates VHL Gene transcription through formation of a complex with VHL and p300 in renal Cancer. Oncotarget 6:6959-6976.

10 - Gumireddy, K., Li, A., Kossenkov, A. V., Cai, K. W., Liu, Q., Yan, J., Xu, H., Showe, L., Zhang, L., Huang, Q. (2014) ID1 promotes breast cancer metastasis by S100A9 regulation. Molecular Cancer Research 12(9):1334-1343.

11 - Hu, X., Feng, Y., Zhang, D., Zhao S. D., Hu, Z., Greshock, J., Zhang, Y., Yang, L., Zhong, X., Wang, L., Jean, S., Li, C., Huang, Q., Katsaros, D., Montone, K. T., Tanyi J. L., Lu, Y., Boyd, J., Nathanson, K. L., Li, H., Mills, G. B., Zhang, L. (2014) A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell 26:344-357.

12 - Yu, G., Li, H., Wang, J., Gumireddy, K., Li, A., Yao, W., Tang, K., Xiao, W., Hu, J., Xiao, H., Lang, B., Ye, Z., Huang, Q., Xu, H. (2014) MicroRNA-34a suppresses cell proliferation and metastasis by targeting CD44 in human renal carcinoma cell. The Journal of Urology 192:1229-1237.

13 - Peng, H., Farrooji, M. T. Z., Osborne, M., Prokop, J., McDonald, P., Karar, J., Hou, Z., He, M., Kebebew, E., Orntoft, T., Herlyn, M., Caton, A., Fredericks, W., Malkowicz, S., Paterno, C., Carolin, A., Speicher, D., Skordalakes, E., Huang, Q., Dedhar, S., Borden, K., Rauscher III, F. (2014) LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase. Cancer Research 74(5):1390-1403.

14 - Gumireddy, K., Li, A., Yan, J., Setoyama, T., Johannes, G. J., Ørom, U. A., Tchou, J., Liu, Q., Zhang, L., Speicher, D. W., Calin, G. A., Huang, Q. (2013) Identification of a long noncoding RNA-associated RNP complex regulating metastasis at the translational Step. EMBO Journal 32:2672-2684.

(Highlighted in EMBO Journal 32:2657-2658)

15 - Yan, J., Gumireddy, K., Li, A., Huang, Q. (2013) Regulation of mesenchymal phenotype by microRNAs in cancer. Current Cancer Drug Targets 13(9):930-934.

16 - Gumireddy, K., Li, A., Cao, L., Yan, J., Liu, L., Xu, X., Pazoles, C., Huang, Q. (2013) NOV-002, a glutathione disulfide mimetic, suppresses tumor cell invasion and metastasis. Journal of Carcinogenesis and Mutagenesis S7:002. doi:10.4172/2157-2158.S7-002.

17 - Hu, X., Guo, J., Zheng, L., Li, C., Zheng, T. M., Tanyi, J. L., Liang, S., Benedetto, C., Mitidieri, M., Katsaros, D., Zhao, X., Zhang, Y., Huang, Q., Zhang, L. (2013) The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer. Molecular Cancer Research 11(3):240-250.

18 - Yan, J., Yang, Q., Huang, Q. (2013) Metastasis suppressor genes. Histology and Histopathology 28(3):285-292.

19 - Yan, J., Huang, Q. (2012) Genomics screens for metastasis genes. Cancer and Metastasis Reviews 31:419-428.

20 - Li, N., Kaur, S. , Greshock, J., Lassus, H., Zhang, X., Wang, Y., Leminen, A., Shao, Z., Hu, X., Shun, L., Katsaros, D., Huang, Q., Bützow, R., Weber, B. L., Coukos, G., Zhang, L. (2012) A combined array-based comparative genomic hybridization and functional library screening approach identified mir-30d as an oncomir in cancer. Cancer Research 72:154-164.

21 - Sundarum, P., Hultine, S., Smith, L. M., Dews, M., Fox, J., Biyashev, D., Schelter, J. M., Huang, Q., Cleary, M. A., Volpert, O., Thomas-Tikhonenko, A. (2011) p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancer. Cancer Research 71:7490-7501.

22 - Chen, J., Sprouffske, K., Huang, Q., Maley, C. (2011) Solving the puzzle of metastasis: The evolution of cell migration in neoplasms. PLoS ONE 6(4):e17933.

23 - Zhong, X., Li, N., Liang, S., Huang, Q., Coukos, G., Zhang, L. (2010) Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells. Journal of Biological Chemistry 285:41961-41971.

24 - Ørom, U. A., Derrien, T., Beringer, M., Gumireddy, K., Gardini, A., Bussotti, G., Lai, F., Zytinicki, M, Notredame, C., Huang, Q., Guigo, R., Shiekhattar, R. (2010) Long noncoding RNAs with enhancer-like function in human cells. Cell 143(1):46-58.

25 - Megraw, M., Sethupathy, P., Gumireddy, K., Jensen, S. T., Huang, Q.*, Hatzigeorgiou, A. G. (2010) Isoform specific gene auto-regulation via miRNAs: a case study on miR-128b and ARPP-21. Theoretical Chemistry Accounts 125:593-598. *corresponding author

26 - Gumireddy, K., Huang, Q. (2010) Identification of metastasis genes by a functional genomics approach. Cell Cycle 9(3):423-423.

27 - Gumireddy, K., Li, A., Gimotty, P. A., Klein-Szanto, A. J., Showe, L. C., Katsaros, D., Coukos, G.,  Zhang, L., Huang, Q. (2009) KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nature Cell Biology 11(11):1297-1304. (Cover article)

28 - Huang, Q. *, Gumireddy, K., Schrier, M., le Sage, C., Nagel, R., Nair, S., Egan, D. A., Li, A., Huang, G., Klein-Szanto, A. J., Gimotty, P. A., Katsaros, D., Coukos, G.,  Zhang, L., Puré, E., Agami, R. (2008) The microRNAs miR-373 and miR-520c Promote Tumor Invasion and Metastasis. Nature Cell Biology 10(2):202-210. *corresponding author

(Highlighted in Cell 132(5):717)

29 - Gumireddy, K., Young, D. D., Xiong, D., Hogenesch, J. B., Huang, Q.*, Deiters, A. (2008) Small Molecule Inhibitors of MicroRNA miR-21 Function. Angewandte Chemie International Edition 47(39):7482-7484. *corresponding author

30 - Yang, N., Kaur, S., Volinia, S., Greshock, J., Lassus, H., Liang, S., Leminen, A., Hasegawa, K., Deng, K., Giannakakis, A., Johnstone, C. N., Chen, X., Liu, C., Huang, Q., Katsaros, D., Calin, G. A., Weber, B. L., Butzow, R., Croce, C. M., Coukos, G., Zhang, L. (2008) MicroRNA Microarray Identifies let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelium Ovarian Cancer. Cancer Research 68: 10307-10314.

31 - Patel, N., Hoang, D., Miller, N., Ansaloni, S., Huang, Q., Rogers, J. T., Lee, J. C., Saunders, A. J. (2008) MicroRNAs Can Regulate Human APP Expression. Molecular Neurodegeneration 3:10.

32 - Zhang, L., Volinia, S., Bonome, T., Calin, G., Greshock, J., Yang, N., Liu, C., Giannakakis, A., Alexiou, P., Hasegawa, K., Johnstone, C., Megraw, M. S., Adams, S., Lassus, H., Huang, J., Kaur, S., Liang, S., Sethupathy, P., Leminen, Simossis, V. A., Sandaltzopoulos, R., Naomoto, Y., Katsaros, D., Gimotty, P., DeMichele, A., Huang, Q., Bützow, R., Rustgi, A. K., Weber, B. L., Birrer, M. J., Hatzigeorgiou, A., Croce, C., Coukos, G. (2008) Genomic and Epigenetic Alterations Deregulate microRNA Expression in Human Epithelial Ovarian Cancer. Proceedings of National Academy of Sciences USA 105: 7004-7009.

33 - Gumireddy, K., Sun, F., Klein-Szanto, A. J., Gibbins, G. M., Gimotty, P. A., Saunders, A. J., Schultz, P. G., Huang, Q. (2007) An in vivo Selection for Metastasis Promoting Genes in the Mouse. Proceedings of National Academy of Sciences USA 104(16): 6696-6701.

34 - Huang, Q., Raya, A., DeJesus, P., Chao, J., Quon, K. C., Caldwell, J. S., Chanda, S. K., Izpisua-Belmonte, J. C., and Schultz, P. G. (2004) Identification of p53 Regulators by Genome-wide Functional Analysis. Proceedings of National Academy of Sciences USA 101(10):3456-3461.

35 - Newman, J. W., Stok, J. E., Vidal, J. D., Corbin, C. J., Huang, Q., Hammock, B. D. and Conley, A. J. (2004) Cytochrome P450-dependent Lipid Metabolism in Pre-ovulatory Follicles. Endocrinology 145:5097-5105.

36 - Chanda, S. K., White, S., Orth, A., Reisdorph, R., Miraglia, L., Thomas, R., DeJesus, P., Mason, D. E., Huang, Q., Vega, R., Yu, D., Nelson, C., Smith, B. M., Terry, R., Linford, A. S., Yu, Y., Chirn, G., Song, C., Labow, M. A., Cohen, D., King, F., Peters, E., Schultz, P. G., Hogenesch, J., and Caldwell, J. S. (2003) Genome-scale Functional Profiling of the Mammalian AP-1 Signaling Pathway. Proceedings of National Academy of Sciences USA 100(21): 12153-12158.

37 - Pei, Z., Reske, G., Huang, Q., Hammock, B. D., Qi, Y., and Chejanovsky, N. (2002) Characterization of the Apoptosis Suppressor Protein P49 from the Spodoptera littoralis nucleopolyhedrovirus. Journal of Biological Chemistry 277(50): 48677-48684.

38 - Huang, Q., Deveraux, Q. L., Maeda, S., Stennicke, H. R., Hammock, B. D., and Reed, J. C. (2001) Cloning and Characterization of a Novel Inhibitor of Apoptosis Protein from Bombyx mori. Biochimica et Biophysica Acta 1499(3):191-198.

39 - Inceoglu, A. B., Kamita, S. G., Hinton, A. C., Huang, Q., Severson, T. F., Kang, K., and Hammock, B. D. (2001) Recombinant Baculoviruses for Insect Control. Pest Management Science 57:981-987.

40 - Huang, Q., Deveraux, Q. L., Maeda, S., Salvesen, G. S., Stennicke, H. R., Hammock, B. D., and Reed, J. C. (2000) Evolutionary Conservation of Apoptosis Mechanism: Lepidopteran and Baculoviral IAPs are Inhibitors of Mammalian Caspase-9. Proceedings of National Academy of Sciences USA 97(4):1427-1432.

41 - Zhang, H., Huang, Q.*, Ke, N., Matsuyama, S., Hammock, B. D., Godzik, A., and Reed, J. C. (2000) Drosophila Pro-apoptotic Bcl-2/Bax Homologue Reveals Evolutionary Conservation of Cell Death Mechanism. Journal of Biological Chemistry 275(35):27303-27306. *co-first author

42 - Hammock, B. D., Kamita, S. G., Inceoglu, A. B., and Huang, Q. (2000) Advantages and Disadvantages of Recombinant Baculoviruses in Insect Pest Control. Phytoparasitica 28(2):191-192.

43 - Lin, J., Deng, G., Huang, Q., and Morser, J. (2000) KIAP, a Novel Member of the Inhibitor of Apoptosis Protein Family. Biochemical and Biophysical Research Communications 279(3):820-831.


Protocol of isolation of protein complexes associated with long non-coding RNAs. Long non-coding RNA: Methods and Protocols. Methods in Molecular Biology series, Humana Press.

Evolution of metastasis. Frontiers of Evolution in Cancer.