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The Wistar Institute

3601 Spruce Street

Philadelphia, PA 19104

 

Office: 215-495-6835

Publications

1 - Gumireddy, K., Li, A., Yan, J., Setoyama, T., Johannes, G. J., Ørom, U. A., Tchou, J., Liu, Q., Zhang, L., Speicher, D. W., Calin, G. A., Huang, Q. (2013) Identification of a long noncoding RNA-associated RNP complex regulating metastasis at the translational Step. EMBO Journal. (in press). 

2 - Gumireddy, K., Li, A., Cao, L., Yan, J., Liu, L., Xu, X., Pazoles, C., Huang, Q. (2013) NOV-002, a glutathione disulfide mimetic, suppresses tumor cell invasion and metastasis. Journal of Carcinogenesis and Mutagenesis S7:002. doi:10.4172/2157-2158.S7-002

3 - Li, N., Kaur, S. , Greshock, J., Lassus, H., Zhang, X., Wang, Y., Leminen, A., Shao, Z., Hu, X., Shun, L., Katsaros, D., Huang, Q., Bützow, R., Weber, B. L., Coukos, G., Zhang, L. (2012) A combined array-based comparative genomic hybridization and functional library screening approach identified mir-30d as an oncomir in cancer. Cancer Research 72:154-164.

4 - Sundarum, P., Hultine, S., Smith, L. M., Dews, M., Fox, J., Biyashev, D., Schelter, J. M., Huang, Q., Cleary, M. A., Volpert, O., Thomas-Tikhonenko, A. (2011) p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancer. Cancer Research 71:7490-7501.

5 - Chen, J., Sprouffske, K., Huang, Q., Maley, C. (2011) Solving the puzzle of metastasis: The evolution of cell migration in neoplasms. PLoS ONE 6(4):e17933.

6 - Zhong, X., Li, N., Liang, S., Huang, Q., Coukos, G., Zhang, L. (2010) Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells. Journal of Biological Chemistry 285:41961-41971.

7 - Ørom, U. A., Derrien, T., Beringer, M., Gumireddy, K., Gardini, A., Bussotti, G., Lai, F., Zytinicki, M, Notredame, C., Huang, Q., Guigo, R., Shiekhattar, R. (2010) Long noncoding RNAs with enhancer-like function in human cells. Cell 143(1):46-58.

8 - Megraw, M., Sethupathy, P., Gumireddy, K., Jensen, S. T., Huang, Q.*, Hatzigeorgiou, A. G. * (2010) Isoform specific gene auto-regulation via miRNAs: a case study on miR-128b and ARPP-21. Theoretical Chemistry Accounts 125:593-598.
*corresponding author

9 - Gumireddy, K., Huang, Q. (2010) Identification of metastasis genes by a functional genomics approach. Cell Cycle 9(3):423-423.

10 - Gumireddy, K., Li, A., Gimotty, P. A., Klein-Szanto, A. J., Showe, L. C., Katsaros, D., Coukos, G.,  Zhang, L., Huang, Q. (2009) KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nature Cell Biology 11(11):1297-1304.(Cover article)

11 - Huang, Q. *, Gumireddy, K., Schrier, M., le Sage, C., Nagel, R., Nair, S., Egan, D. A., Li, A., Huang, G., Klein-Szanto, A. J., Gimotty, P. A., Katsaros, D., Coukos, G.,  Zhang, L., Puré, E., Agami, R. * (2008) The microRNAs miR-373 and miR-520c Promote Tumor Invasion and Metastasis. Nature Cell Biology 10(2):202-210.
*corresponding author
(Highlighted in Cell 132(5):717)

12 - Gumireddy, K., Young, D. D., Xiong, D., Hogenesch, J. B., Huang, Q.*, Deiters, A. * (2008) Small Molecule Inhibitors of MicroRNA miR-21 Function. Angewandte Chemie International Edition 47(39):7482-7484.
*corresponding author

13 - Yang, N., Kaur, S., Volinia, S., Greshock, J., Lassus, H., Liang, S., Leminen, A., Hasegawa, K., Deng, K., Giannakakis, A., Johnstone, C. N., Chen, X., Liu, C., Huang, Q., Katsaros, D., Calin, G. A., Weber, B. L., Butzow, R., Croce, C. M., Coukos, G., Zhang, L. (2008) MicroRNA Microarray Identifies let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelium Ovarian Cancer. Cancer Research 68: 10307-10314.

14 - Patel, N., Hoang, D., Miller, N., Ansaloni, S., Huang, Q., Rogers, J. T., Lee, J. C., Saunders, A. J. (2008) MicroRNAs Can Regulate Human APP Expression. Molecular Neurodegeneration 3:10.

15 - Zhang, L., Volinia, S., Bonome, T., Calin, G., Greshock, J., Yang, N., Liu, C., Giannakakis, A., Alexiou, P., Hasegawa, K., Johnstone, C., Megraw, M. S., Adams, S., Lassus, H., Huang, J., Kaur, S., Liang, S., Sethupathy, P., Leminen, Simossis, V. A., Sandaltzopoulos, R., Naomoto, Y., Katsaros, D., Gimotty, P., DeMichele, A., Huang, Q., Bützow, R., Rustgi, A. K., Weber, B. L., Birrer, M. J., Hatzigeorgiou, A., Croce, C., Coukos, G. (2008) Genomic and Epigenetic Alterations Deregulate microRNA Expression in Human Epithelial Ovarian Cancer. Proceedings of National Academy of Sciences USA 105: 7004-7009.

16 - Gumireddy, K., Sun, F., Klein-Szanto, A. J., Gibbins, G. M., Gimotty, P. A., Saunders, A. J., Schultz, P. G., Huang, Q. (2007) An in vivo Selection for Metastasis Promoting Genes in the Mouse. Proceedings of National Academy of Sciences USA 104(16): 6696-6701.

17 - Huang, Q., Raya, A., DeJesus, P., Chao, J., Quon, K. C., Caldwell, J. S., Chanda, S. K., Izpisua-Belmonte, J. C., and Schultz, P. G. (2004) Identification of p53 Regulators by Genome-wide Functional Analysis. Proceedings of National Academy of Sciences USA 101(10):3456-3461.

18 - Newman, J. W., Stok, J. E., Vidal, J. D., Corbin, C. J., Huang, Q., Hammock, B. D. and Conley, A. J. (2004) Cytochrome P450-dependent Lipid Metabolism in Pre-ovulatory Follicles. Endocrinology 145:5097-5105.

19 - Chanda, S. K., White, S., Orth, A., Reisdorph, R., Miraglia, L., Thomas, R., DeJesus, P., Mason, D. E., Huang, Q., Vega, R., Yu, D., Nelson, C., Smith, B. M., Terry, R., Linford, A. S., Yu, Y., Chirn, G., Song, C., Labow, M. A., Cohen, D., King, F., Peters, E., Schultz, P. G., Hogenesch, J., and Caldwell, J. S. (2003) Genome-scale Functional Profiling of the Mammalian AP-1 Signaling Pathway. Proceedings of National Academy of Sciences USA 100(21): 12153-12158.

20 - Pei, Z., Reske, G., Huang, Q., Hammock, B. D., Qi, Y., and Chejanovsky, N. (2002) Characterization of the Apoptosis Suppressor Protein P49 from the Spodoptera littoralis nucleopolyhedrovirus. Journal of Biological Chemistry 277(50): 48677-48684.

21 - Huang, Q., Deveraux, Q. L., Maeda, S., Stennicke, H. R., Hammock, B. D., and Reed, J. C. (2001) Cloning and Characterization of a Novel Inhibitor of Apoptosis Protein from Bombyx mori. Biochimica et Biophysica Acta 1499(3):191-198.

22 - Inceoglu, A. B., Kamita, S. G., Hinton, A. C., Huang, Q., Severson, T. F., Kang, K., and Hammock, B. D. (2001) Recombinant Baculoviruses for Insect Control. Pest Management Science 57:981-987.

23 - Huang, Q., Deveraux, Q. L., Maeda, S., Salvesen, G. S., Stennicke, H. R., Hammock, B. D., and Reed, J. C. (2000) Evolutionary Conservation of Apoptosis Mechanism: Lepidopteran and Baculoviral IAPs are Inhibitors of Mammalian Caspase-9. Proceedings of National Academy of Sciences USA 97(4):1427-1432.

24 - Zhang, H. *, Huang, Q.*, Ke, N., Matsuyama, S., Hammock, B. D., Godzik, A., and Reed, J. C. (2000) Drosophila Pro-apoptotic Bcl-2/Bax Homologue Reveals Evolutionary Conservation of Cell Death Mechanism. Journal of Biological Chemistry 275(35):27303-27306.
*co-first author

25 - Hammock, B.D., Kamita, S. G., Inceoglu, A. B., and Huang, Q. (2000) Advantages and Disadvantages of Recombinant Baculoviruses in Insect Pest Control. Phytoparasitica 28(2):191-192.

26 - Lin, J., Deng, G., Huang, Q., and Morser, J. (2000) KIAP, a Novel Member of the Inhibitor of Apoptosis Protein Family. Biochemical and Biophysical Research Communications 279(3):820-831.