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The Wistar Institute

3601 Spruce Street

Philadelphia, PA 19104

 

Office: 215-898-3926

Fax: 215-573-2097

 

Publications

Research Publications, peer reviewed:

Adams, J.W., Kaufman, R.E., Kretschmer, P.J., Harrison, M., Nienhuis, A.W.: A family of long reiterated DNA sequences, one copy of which is next to the human beta globin gene. Nucleic Acids Res 8:6113-6128, 1980.

Kaufman, R.E., Kretschmer, P.J., Adams, J.W., Coon, H.C., Anderson, W.F., Nienhuis, A.W.: Cloning and characterization of DNA sequences surrounding the human gamma-, delta-, and beta-globin genes. Proc Natl Acad Sci U S A 77:4229-4233, 1980.

Kretschmer, P.J., Kaufman, R.E., Coon, H.C., Chen, M.J., Geist, C.E., Nienhuis, A.W.: Hemoglobin switching in sheep. Cloning and characterization of the beta A and beta-like embryonic globin genes from genomic DNA. J Biol Chem 255:3204-3211, 1980.

Tam, J.W., Kaufman, R.E., Nienhuis, A.W.: Analysis of globin gene structure in patients with beta thalassemia by restriction endonuclease mapping. Hemoglobin 5:209-215, 1981.

Kaufman, R.E.: Prenatal diagnosis of hemoglobinopathies and thalassemias. N.C. Medical Genetics Association, Inc. 2, 1984.

Tajima, S., Ting, J.P., Pinnell, S.R., Kaufman, R.E.: Isolation and characterization of a human pro alpha 2(I) collagen gene segment. J Invest Dermatol 82:265-269, 1984.

Atweh, G.F., Anagnou, N.P., Shearin, J., Forget, B.G., Kaufman, R.E.: Beta-thalassemia resulting from a single nucleotide substitution in an acceptor splice site. Nucleic Acids Res 13:777-790, 1985.

Grobler-Rabie, A.F., Brebner, D.K., Vandenplas, S., Wallis, G., Dalgleish, R., Kaufman, R.E., Bester, A.J., Mathew, C.G., Boyd, C.D.: Polymorphism of DNA sequence in the human pro alpha 2(I) collagen gene. J Med Genet 22:182-186, 1985.

Henke, E., Leader, M., Tajima, S., Pinnell, S., Kaufman, R.: A 38 Base Pair Insertion in the Proalpha-2(I) Collagen Gene of a Patient with Marfan-Syndrome. J Cell Biochem 27:169-174, 1985.

Kaufman, R., Henke, E., Duvic, M., Bisat, F., Pinnell, S.: Normal and Mutant Human Collagen Genes. Ann NY Acad Sci 460:461-462, 1985.

Lobach, D.F., Bolognesi, D.P., Kaufman, R.E.: Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus. Cancer Invest 3:145-160, 1985.

Didsbury, J.R., Theil, E.C., Kaufman, R.E., Dickey, L.F.: Multiple red cell ferritin mRNAs, which code for an abundant protein in the embryonic cell type, analyzed by cDNA sequence and by primer extension of the 5'-untranslated regions. J Biol Chem 261:949-955, 1986.

Introna, M., Hamilton, T.A., Kaufman, R.E., Adams, D.O., Bast, R.C., Jr.: Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes. J Immunol 137:2711-2715, 1986.

McCachren, S.S., Jr., Nichols, J., Kaufman, R.E., Niedel, J.E.: Dibutyryl cyclic adenosine monophosphate reduces expression of c-myc during HL-60 differentiation. Blood 68:412-416, 1986.

Williams, R.S., Salmons, S., Newsholme, E.A., Kaufman, R.E., Mellor, J.: Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle. J Biol Chem 261:376-380, 1986.

Dickey, L.F., Sreedharan, S., Theil, E.C., Didsbury, J.R., Wang, Y.H., Kaufman, R.E.: Differences in the regulation of messenger RNA for housekeeping and specialized-cell ferritin. A comparison of three distinct ferritin complementary DNAs, the corresponding subunits, and identification of the first processed in amphibia. J Biol Chem 262:7901- 7907, 1987.

Kaufman, R.E.: Characterization of fetal-type acetylcholinesterase in hemin-treated K562 cell-culture - commentary. Blood Cells 12:653-655, 1987.

Markert, M.L., Hershfield, M.S., Wiginton, D.A., States, J.C., Ward, F.E., Bigner, S.H., Buckley, R.H., Kaufman, R.E., Hutton, J.J.: Identification of a deletion in the adenosine deaminase gene in a child with severe combined immunodeficiency. J Immunol 138:3203-3206, 1987.

Meadows, L.M., Ozer, H., Kaufman, R.E.: The story of interferon. North Carolina Medical Journal 48:381-386, 1987.

Geesin, J.C., Darr, D., Kaufman, R., Murad, S., Pinnell, S.R.: Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol 90:420-424, 1988.

Markert, M.L., Hutton, J.J., Wiginton, D.A., States, J.C., Kaufman, R.E.: Adenosine deaminase (ADA) deficiency due to deletion of the ADA gene promoter and first exon by homologous recombination between two Alu elements. J Clin Invest 81:1323-1327, 1988.

Ortel, T.L., Onorato, J.J., Bedrosian, C.L., Kaufman, R.E.: Antifibrinolytic therapy in the management of the Kasabach Merritt syndrome. Am J Hematol 29:44-48, 1988.

Phillips, G., Jr., Hartman, J., Kinney, T.R., Sokal, J.E., Kaufman, R.E. : Chronic granulocytic leukemia in a patient with sickle cell anemia. Am J Med 85:567-569, 1988.

Kinney, T.R., Sawtschenko, M., Whorton, M., Shearin, J., Stine, C., Hofman, L., Safko, R., Vitaglione, T., Kaufman, R.E.: Newborn screening for sickle cell disease and other hemoglobinopathies. Techniques' comparison and report of the North Carolina experience. Pediatrics 83:843-848, 1989.

Meadows, L.M., Rosse, W.R., Moore, J.O., Crawford, J., Laszlo, J., Kaufman, R.E.: Hodgkin's disease presenting as myelofibrosis. Cancer 64:1720-1726, 1989.

Sykes, K., Kaufman, R.: A human gamma globin gene variant binds SP1. Prog Clin Biol Res 316A:237-246, 1989.

Meadows, L.M., George, D.J., Kaufman, R.E.: Dissociation of thymidine incorporation and transferrin receptor expression from cell growth and c-myc accumulation in alpha-interferon-treated cells. J Biol Response Mod 9:212-220, 1990.

Sykes, K., Kaufman, R.: A naturally occurring gamma globin gene mutation enhances SP1 binding activity. Mol Cell Biol 10:95-102, 1990.

Schanberg, L.E., Fleenor, D.E., Kurtzberg, J., Haynes, B.F., Kaufman, R.E.: Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. Proc Natl Acad Sci U S A 88:603-607, 1991.

Tyson, F.L., Boyer, C.M., Kaufman, R., O'Briant, K., Cram, G., Crews, J.R., Soper, J.T., Daly, L., Fowler, W.C., Jr., Haskill, J.S., et al.: Expression and amplification of the HER-2/neu (c-erbB-2) protooncogene in epithelial ovarian tumors and cell lines. Am J Obstet Gynecol 165:640-646, 1991.

deCastro, C.M., Vandenbark, G.R., Kaufman, R.E.: Detection of the KIT protooncogene receptor on human hematopoietic progenitor cells using the monoclonal-antibody 9b9. Exp Hematol 20:111, 1992.

Kaufman, R.E.: Hydroxyurea: specific therapy for sickle cell anemia? Blood 79:2503-2506, 1992.

Petranka, J.G., Fleenor, D.E., Sykes, K., Kaufman, R.E., Rosse, W.F.: Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. Proc Natl Acad Sci U S A 89:7876-7879, 1992.

Vandenbark, G.R., deCastro, C.M., Taylor, H., Dew-Knight, S., Kaufman, R.E.: Cloning and structural analysis of the human c-KIT gene. Oncogene 7:1259-1266, 1992.

Bentley, R.C., Devlin, B., Kaufman, R.E., Borowitz, M., Ratech, H.: Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes. Hum Pathol 24:675-678, 1993.

Bowen, D.T., Padua, R.A., Burnett, A.K., deCastro, C.M., Kaufman, R.E.: Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots. Leukemia 7:1883-1885, 1993.

Fleenor, D.E., Kaufman, R.E.: Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain. Blood 81:2781-2790, 1993.

de Castro, C.M., Devlin, B., Fleenor, D.E., Lee, M.E., Kaufman, R.E.: A novel beta- globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype. Blood 83:1109-1116, 1994.

deCastro, C.M., Denning, S.M., Langdon, S., Vandenbark, G.R., Kurtzberg, J., Scearce, R., Haynes, B.F., Kaufman, R.E.: The c-KIT proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes. Exp Hematol 22:1025-1033, 1994.

Devlin, B.H., Ratech, H., Kaufman, R.: Inclusion of a sensitivity control to add a quality-control parameter and improve reproducibility in BCR, immunoglobulin, and T-cell receptor gene-rearrangement studies. Diagn Mol Pathol 3:271-274, 1994.

Schanberg, L.E., Lee, D.M., Fleenor, D.E., Ware, R.E., Patel, D.D., Haynes, B.F., Kaufman, R.E.: Characterization of human CD7 transgenic mice. J Immunol 155:2407- 2418, 1995.

Sundv, J.S., Barry, T.S., Patel, D.D., Allen, N.B., Devlin, B., Bigner, S., Kaufman, R.E., Haynes, B.F. Myotropic Th1 T helper cell lymphoma presenting as granulomatous inflammatory masses in synovium and muscle. J Invest Med 44:232a, 1996.

Fleenor, D.E., Langdon, S.D., deCastro, C.M., Kaufman, R.E.: Comparison of human and Xenopus GATA-2 promoters. Gene 179:219-223, 1996.

Fleenor, D.E., Schanberg, L.E., Kaufman, R.E.: A conserved element in the human CD7 promoter binds dbpA and a novel zinc finger protein. Blood 88:770, 1996.

Lee, D.M., Schanberg, L.E., Fleenor, D.E., Seldin, M.F., Haynes, B.F., Kaufman, R.E.: The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters. Immunogenetics 44:108-114, 1996.

Vandenbark, G.R., Chen, Y., Friday, E., Pavlik, K., Anthony, B., deCastro, C., Kaufman, R.E.: Complex regulation of human c-KIT transcription by promoter repressors, activators, and specific myb elements. Cell Growth Differ 7:1383- 1392, 1996.

de Castro, C.M., Rabe, S.M., Langdon, S.D., Fleenor, D.E., Slentz-Kesler, K., Ahmed, M.N., Qumsiyeh, M.B., Kaufman, R.E.: Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). Genomics 42:227-235, 1997.

Ratech, H., Denning, S., Kaufman, R.E.: An analysis of alternatively spliced CD45 mRNA transcripts during T cell maturation in humans. Cell Immunol 177:109- 118, 1997.

Langdon, S.D., Kaufman, R.E.: Gamma-globin gene promoter elements required for interaction with globin enhancers. Blood 91:309-318, 1998.

Slentz-Kesler, K.A., Hale, L.P., Kaufman, R.E.: Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms. Genomics 47:327-340, 1998.

Kaufman, R.E.: Synthesis of sickle and normal hemoglobins: Laboratory and clinical implications. Laboratory Medicine 30:129-133, 1999.

Sempowski, G.D., Lee, D.M., Kaufman, R.E., Haynes, B.F.: Structure and function of the CD7 molecule. Crit Rev Immunol 19:331-348, 1999.

Kaufman, R.E., Petrusa, E.R.: Duke University School of Medicine. Acad Med 75:S265-267, 2000.

Lam, G.K., Liao, H.X., Xue, Y., Alam, S.M., Scearce, R.M., Kaufman, R.E., Sempowski, G.D., Haynes, B.F.: Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma. J Clin Immunol 25:41-49, 2005.

Wang, T., Huang, C., Lopez-Coral, A., Slentz-Kesler, K.A., Xiao, M., Wherry, E.J., Kaufman, R.E.: K12/SECTM1, an interferon regulated molecule, synergizes with CD28 to costimulate human T cell proliferation. J Leukoc Biol 91:449-459, 2012.

Wang, T., Ge, Y., Xiao, M., Lopez-Coral, A., Azuma, R., Somasundaram, R., Zhang, G., Wei, Z., Xu, X., Rauscher, FJ 3rd, Herlyn, M., Kaufman, R.E.: Melanoma-derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signature. Pigment Cell Melanoma Res 25:493-505, 2012.

Ge, Y., Azuma, R., Gekonge, B., Lopez-Coral, A., Xiao, M., Zhang, G., Xu, X., Montaner, L., Wei, Z., Herlyn, M., Wang, T., Kaufman, Russel E.: Induction of metallothionein expression during monocyte to melanoma-associated macrophage differentiation. Front. Biol 7(4): 359–367, 2012.

Tao Wang, Yingbin Ge, Min Xiao, Alfonso Lopez-Coral, Ling Li, Alexander Roesch, Catherine Huang, Peter Alexander, Thomas Vogt, Xiaowei Xu, Wei-Ting Hwang, Melissa Lieu, Eric Belser, Rui Liu, Rajasekharan Somasundaram, Meenhard Herlyn, Russel E. Kaufman. SECTM1 Produced by Tumor Cells Attracts Human Monocytes Via CD7-mediated Activation of the PI3K Pathways. (In Press [September 2013] J. Investigative Biology).

 

Manuscripts in Review:

Tao Wang, Min Xiao, Yingbin Ge, Clemens Krepler, Xiaowei Xu, Gao Zhang, Rikka Azuma, Sanika Khare, Qin Liu, Ling Li, Ravi K. Amaravadi, Wei Xu, Giorgos Karakousis, Tara C. Gangadhar, Lynn Mara Schuchter, Molly B. Halloran, Meenhard Herlyn, Russel E. Kaufman. BRAF inhibition stimulates melanoma-associated macrophages to drive tumor growth.

 

Research Publications, peer-reviewed reviews:

Adams, J.W., Kaufman, R.E., Kretschmer, P.J., Coon, H.C., Anderson, W.F., Nienhuis, A.W.: Cloning and characterization of the sequences surrounding the human b-like globin genes: Identification of an unusually long moderaly repetitive DNA sequence in Stamatoyannopoulos, G., Nienhuis, A. W. (Ed.) Organization and Expression of Globin Genes, Alan R. Liss, Inc., New York, 1981, pp. 33-43.

Kantor, J.A., Kaufman, R.E., Turner, P.H., Farquhar, M.: Processing of g, d and b-globin mRNA precursors in human fetal, normal adult and b+-thalassemia erythroid cells in Stamatoyannopoulos, G., Nienhuis, A. W. (Ed.) Organization and Expression of Globin Genes, Alan R. Liss, Inc., New York, 1981, pp. 219-230.

Nienhuis, A.W., Kretschmer, P.J., Kaufman, R.E., Kantor, J.A., Coon, H.C., Goldsmith, M.: Structure and expression of globin genes in Fiorelli, J. J., Gorini, G. (Ed.) Advances in Red Blood Cell Biology, Raven Press, New York, 1982, pp. 165-175.

Shull, G.E., Didsbury, J.R., Kaufman, R.E., Valaitis, A.P., Theil, E.C.: Regulation of ferritin mRNA and iron status in Urushizaki, I., Aisen, P., Listowsky, J., Drysdale, J. W. (Ed.) Structure and Function of Iron Storage and Transport Proteins, Elsevier, New York, 1983, pp. 105-189.

Fleenor, D.E., Kaufman, R.E.: Chromosomal organization of the beta globin gene domain in The Regulation of Hemoglobin Switching, The Johns Hopkins University Press, Baltimore, 1991, pp. 178-193.

Kaufman, R.E.: Analysis of abnormal hemoglobins in Practical Laboratory Hematology, Churchill Livingstone, Inc., New York, 1991, pp. 251-294.

 

Editorials, Reviews, Chapters:

Kaufman, R., E.: Commentaries on the pre-award process of funding research in Reducing Bureaucratic Accretion in Government and University Procedures for Sponsored Research, National Academy Press, Washington DC, 1983, pp. 33-35.

Marshall, Burke et al. Strengthening the Government-University Partnership in Science: Report of the Ad Hoc Committee on Government-University Relationships in Support of Science. National Academy Press, Washington, DC, 1983, pp. 1-234.

Kaufman, R.E.: Thalassemia in Conn's Current Therapy, W.B. Saunders, Philadelphia, 1984, pp. 249-252.

Kaufman, R.E.: Thalassemia in Conn's Current Therapy, W.B. Saunders, Philadelphia, 1986, pp. 282-286.

Kaufman, R.E.: Gene expression and recombinant DNA in Textbook of Internal Medicine, J.B. Lippincott, 1989, pp. 2144-2146.

Adkinson, F., Alpert, J., Loriaux, L., Ladenson, P.W., Friedman, L.S., Cassileth, P., Kaufman, R.E., Bartlett, J., Klempner, M., Neilson, E.G., Glick, J., Mayer, R., Koerner, S., Crandell, W., Arend, W.: Training in subspecialty internal medicine - on the chessboard of health care reform. ASP/AIM Position Paper approved by Council, Association of Subspecialty Professors. Ann Intern Med 121:810-813, 1994.

Phillips, G., Kaufman, R.E.: Thalassemia.  In “Conn's Current Therapy.”   W.B. Saunders, Houston, 1994, pp. 345-350.

Telen, M.J., Kaufman, R.E.: The mature erythrocyte function in Wintrobe Hematology, Williams & Wilkins, Baltimore, 1998, pp. 193-227.

Telen, M.J., Kaufman, R.E.: The mature erythrocyte function in Wintrobe Hematology, Lippincott Williams & Wilkins, 2003, pp. 217-247.

Kaufman, R.E.: Conflict of Interest Task Force Report. AAMC, 2001.