Jan Erikson, Ph.D.
Jan Erikson, Ph.D.
- Professor, Vaccine Center
- Member, Tumor Microenvironment and Metastasis Program
- 215-898-3823, Office
The laboratory of Jan Erikson has had a long-standing interest in B cell activation and regulation, particularly the signals that guide the trajectory of immune cells along distinct developmental paths resulting in either short-term or long-lasting immunity. Antibody secreting cells (ASCs) are pivotal in the etiology of antibody-mediated autoimmune syndromes such as SLE, and the malignant transformation of ASCs results in multiple myeloma. Furthermore, protective humoral immunity to viral infections depends on long-lived ASCs. The mechanisms responsible for the generation and maintenance of ASCs in survival niches at inflamed sites and the bone marrow remain poorly understood.
The Erikson lab has focused on the regulation of autoreactive disease-associated B cells, specifically anti-chromatin B cells that are one of the hallmarks of lupus as well as the immune response to respiratory tract (RT) infections, which remain a major health burden worldwide. Protective immunity to RT infections depends on long-lived (ASCs) and memory B cells.
The Erikson lab is beginning to identify features of RT infection that promote B cell and ASC survival. Because a significant cause of morbidity and mortality with influenza infection is due to bacterial co-infection, the lab has established a model of influenza-bacterial co-infection. They have documented that co-infection modulates the humoral immunity to influenza infection. Understanding how B cells interpret the co-infection milieu may inform future vaccine approaches for infectious diseases as well as therapies for B cell-based autoimmunity and myeloma.
Erikson received both her bachelor’s degree and doctorate in biology from the University of Pennsylvania. In 1986, she moved to California to do her initial postdoctoral work at Stanford University Medical School, and later returned to Pennsylvania for a postdoctoral fellowship at the Institute for Cancer Research, Fox Chase Cancer Center.
Erikson joined The Wistar Institute as an assistant professor in 1991. A year later, she was named Wistar Institute Assistant Professor of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine.
1. Bedoya F, Cheng G-S, Leibow A, Zakhary N, Weissler K, Garcia V, Aitken M, Kropf E, Garlick DS, Wherry JE, Erikson J, Caton AJ. 2013. Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice. J Immunol. 2013 May 10. doi:10.4049/jimmunol.1203302 [Epub ahead of print] PMID: 23667113
2. Laidlaw BJ, Decman V, Ali MA, Abt MC, Wolf AI, Monticelli LA, Mozdzanowska K, Angelosanto JM,Artis D, Erikson J, Wherry EJ. Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity. PLoS Pathog 2013,9(3): e1003207. PMID: 23516357
3. Abt MC, Osborne LC, Monticelli LA, Doering TA, Alenghat T, Sonnenberg GF, Paley MA, Antenus M, Williams KL, Erikson J, Wherry EJ, Artis D. 2012. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity. 37:158-170. PMID: 22705104
4. Wolf AI, Mozdzanowska K, Williams KL, Singer D, Hoffmann R, Caton AJ, Otvos L, Erikson J. 2011. Vaccination with M2e-based multiple antigenic peptides: Characterization of the B cell response and protection efficacy in inbred and outbred mice. PLoS ONE. 6: e28445. PMID: 22180783. PMCID: PMC3236751
5. Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI. Wolf AI, Mozdzanowska K, J Quinn W 3rd, Metzgar M, Williams KL, Caton AJ, Meffre E, Bram RJ, Erickson LD, Allman D, Cancro MP, Erikson J. J Clin Invest. 2011 Oct 3;121(10):3954-64. PMID: 21881204
6. Cozzo Picca C, Simons DM, Oh S, Aitken M, Perng OA, Mergenthaler C, Kropf E, Erikson J, Caton AJ. CD4⁺CD25⁺Foxp3⁺ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14890-5. PMID: 21873239
7. Cheng G, Wang LC, Fridlender ZG, Cheng GS, Chen B, Mangalmurti NS, Saloura V, Yu Z, Kapoor V, Mozdzanowska K, Moon E, Sun J, Kreinder JL, Cohen NA, Caton AJ, Erikson J, Albelda SM., Pharmacologic activation of the Innate Immune System to prevent respiratory viral infections., American Journal of Respiratory Cell and Molecular Biology. 2010 Dec 10. [Epub ahead of print], PMID: 21148741
8. Zhou D, Wu TL, Lasaro MO, Latimer BP, Parzych EM, Bian A, Li Y, Li H, Erikson J, Xiang Z, Ertl HC., A universal Influenza A vaccine based on Adenovirus expressing Matrix-2 Ectodomain and Nucleoprotein Protects mice from letal challenge., Molecular Therapy. 2010 Dec;18(12):2182-9. [Epub 2010 Sep 28], PMID: 20877342
9. Simons DM, Picca CC, Oh S, Perng OA, Aitken M, Erikson J, Caton AJ., How specificity for self-peptides shapes the development and function of regulatory T cells., Journal of Leukocyte Biology. 2010 Dec;88(6):1099-107. [Epub 2010 May 21], 20495071
10. Decman V, Laidlaw BJ, Dimenna LJ, Abdulla S, Mozdzanowska K, Erikson J, Ertl HC, Wherry EJ., Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection., Journal of Immunology. 2010 May 1;184(9):5151-9. [Epub 2010 Apr 5] , PMID: 20368274
11. Sonnenberg GF, Mangan PR, Bezman NA, Sekiguchi DR, Luning Prak ET, Erikson J, Maltzman JS, Jordan MS, Koretzky GA., Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production., Blood. 2010 Mar 18;115(11):2186-95. [Epub 2009 Dec 22] , PMID:20029045
12 Hondowicz BD, Batheja AO, Metzgar MH, Caton AJ, Erikson J., ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice., Journal of Autoimmunity. 2010 Jun;34(4):460-8. [Epub 2009 Dec 22] , PMID:20022728
13. Hondowicz BD, Batheja AO, Metzgar MH, Pagán AJ, Perng OA, Willms S, Caton AJ, Erikson J., Efficient help for autoreactive B-cell activation requires CD4+ T-cell recognition of an agonist peptide at the effector stage., European Journal of Immunology. 2009 Sep;39(9):2377-82., PMID: 19662636
14. Mandik-Nayak L, Ridge N, Fields M. Park AY, Erikson J., Role of B cells in systemic lupus erythematosus and rheumatoid arthritis., Current Opinion in Immunology. 2008 Dec;20(6):639-45. [Epub 2008 Sep 18], 18775493
15. Hondowicz BD, Fields ML, Nish SA, Larkin J, Caton AJ, Erikson J., Autantibody production in lpr/lpr gld/gld mice reflects accumulation of CD4(+) effector cells that are resistant to regulatory T cell activity., Journal of Autoimmunity. 2008 Sep;31(2):98-109. [E-pub 2008 June 6], PMID: 18539433
16. Khan SN, Witsch EJ, Goodman NG, Panigrahi AK, Erikson J, Weigert M, Prak ET, Radic M., Editing and escape from editing in anti-DNA B cells., Proceedings of the National Academey of the Sciences, U.S.A. 2008 March 11; 105(10):3861-6. [Epub 2008 Feb 29], PMID: 18310318