Monoclonal Antibodies to ADAR

Tech ID
NK9480
Background

Adenosine Deaminase Acting on RNA (ADAR) is a member of a gene family that is involved in site-selective RNA editing that changes adenosine residues to inosine.  Three vertebrate ADAR gene family members, ADAR1, ADAR2,and ADAR3, have been identified.  ADAR1 and ADAR2 form a stable enzymatically active homodimer complex and ADAR3is a monomeric, enzymatically inactive form.

 

anti-ADAR1 (made against dsRNA binding domain region)

Clone

Isotype

Tested In

 

 

 

15.8.6

IgG

Western Blot & Immunohistochemistry

 

References:    

 

Q. Wang et al.  (2000)  Requirement of the RNA Editing Deaminase ADAR1 Gene for Embryonic Erythropoiesis, Science Vol. 290, 1765-1768

 

Dan-Sung C. Cho et al. (2003)  Requirement of Dimerization for RNA Editing Activity of Adenosine Deaminases Acting on RNA, The Journal of Biological Chemistry Vol. 278 No. 19, 17093-17102

 

anti-ADAR2 (made against N-terminal region)

Clone

Isotype

Tested In

 

 

 

1.3.1

IgG

Western Blot & Immunohistochemistry

 

References:    

 

Dan-Sung C. Cho et al. (2003)  Requirement of Dimerization for RNA Editing Activity of Adenosine Deaminases Acting on RNA, The Journal of Biological Chemistry Vol. 278 No. 19, 17093-17102

 

anti-ADAR3 (made against N-terminal region)

Clone

Isotype

Tested In

 

 

 

3.591

IgG

Western Blot

 

References:    

 

Chun-Xia Chen et al.  (2000)  A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains, RNA Vol. 6, 755-767

Key Words
ADAR, adenosine deaminase, RNA Editing
Intellectual Property Status

This technology is protected by U.S. Patent Nos. 5,643,778; 5,677,428; and 5,763,174.

Licensing Opportunity

These antibodies are available for non-exclusive license for research use.