Monoclonal Antibodies For Influenza Research

Inventor(s)
Tech ID
GW0301, GW01RR
Background

Characteristics: These antibodies specifically bind to the identified antigens on influenza viruses. All of the antibodies are useful for ELISA and some of the antibodies are also useful for Western blot. The specificity of the various antibodies that have been characterized is as shown:

 

Antibody

Isotype

Specificity

Reference

 

H36-4-5.2

IgG2a/k

H1 (PR8)

2, 3, 5, 7-8, 11

 

NA-112-S2.4

IgG2a/k

N1 (PR8)

9

 

H15-B9-22

IgG2a/k

H1 (WSN)

6

 

CM1-4

IgG2b/k

H1 (110-120)

 
   

Reacts with 1934-1957 strains

 
   

Later strains nd

 
 

H14-A21-1R1

G1/k

H3 (Aichi/68, Mem/72, others nd)

4

 

M1-1C6-5

G1/k

M1

1

H18-S12-3

G2a/k

M1

1

 

M2-56

G2a/k

M2

10

 

H16-L10-4R5

G2a/k

NP (x-reacts with PR8 and Aichi)

1

H19-S24-4

G2a/k

NP (x-reacts with early H1N1 strains)

1

 

1.1B8

G2a/k

H (B/Lee)

 

 

References:

 

1. Yewdell, J.W., Frank, E., and Gerhard, W. J. Immunol. 126: 1814-1819, 1981.

 

2. Gerhard, W., Yewdell, J., Frankel, M., and Webster, R.G. Nature 290: 713-717, 1981.

 

3. Caton, A.J., Brownlee, G.G., Yewdell, J.W., and Gerhard, W. Cell 31: 417-427, 1982.

 

4. Jackson, D.C., Murray, J.M., White, D.O., and Gerhard, W. Infec. and Immunity 37: 912-918, 1982.

 

5. Staudt, L.M. and Gerhard, W. J. Exp. Med. 157: 687-704, 1983

 

6. Nohinek et al. Virology 143: 651-656, 1985.

 

7. Kavaler J et al. J. Immunol. 145: 2312-2321, 1990.

 

8. Caton, A.J., Stark, S.E., Kavaler, J., Staudt, L.M., Schwartz, D., and Gerhard, W. J. Immunol. 147: 1675-1687, 1991.

 

9. Mozdzanowska et al. Virology 254: 138-146, 1999.

 

10. Zhang, M., Zharikova, D., Mozdzanowska, K., Otvos, L., and Gerhard, W. Mol. Immunol. 43: 2195-2206, 2006.

 

11. Mozdzanowska, K., Feng, J., Eld, M., Zharikova, D., Gerhard, W. Virology (in press), 2006.

 

Key Words
influenza, Monoclonal Antibodies, Research Tools
Licensing Opportunity

These antibodies are available for non-exclusive license for research or diagnostic use.