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The Wistar Institute

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Innovative Synthetic DNA-based Cancer Immunotherapy Approach Shows Tumor-clearing Ability in Preclinical Models

PHILADELPHIA — (April 18, 2019) — Wistar scientists have developed a novel synthetic DNA approach for patient-specific production of cancer-targeting molecules called bispecific T cell engagers. DNA-encoded bispecific T cell engagers (dBiTEs) design…
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Identification of a Critical Regulator of Immune Suppressive Cells Reveals a Novel Target for Cancer Immunotherapy

PHILADELPHIA — (April 17, 2019) — Wistar scientists have identified a critical regulator of the function of myeloid derived suppressive cells (MDSCs), opening new opportunities for specific therapeutic targeting of these cells to inhibit tumor growt…
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Synthetic DNA-encoded Antibodies Against Zika Virus Shown to be Effective in Preclinical Studies

PHILADELPHIA — (Apr. 5, 2019) — A new approach for delivery of DNA-encoded monoclonal antibodies (DMAbs) has been reported by Wistar scientists and their collaborators. This new technology allows direct production of monoclonal antibody-like molecul…
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In Memory of Harold Davis, an Extraordinary Wistar Supporter

The Wistar community mourns the loss of a dear friend and one of our greatest supporters, who has given of himself generously to help Wistar for more than four decades. Harold (Hal) M. Davis passed away on Wednesday, Feb. 27, 2019. A succe…
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Wistar and the Philadelphia Zoo Work Together to Improve Global Health

The Wistar Institute and the Philadelphia Zoo employ different preventative approaches to improve the health of humans and animals around the world. The Zoo uses conservation and education while Wistar uses biomedical research in vaccines and infect…
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New Small Molecule Inhibitors Show Potential for Treatment of Epstein-Barr Virus-Associated Cancers

PHILADELPHIA — (March 6, 2019) — Researchers at The Wistar Institute have created a drug candidate for cancers associated with Epstein-Barr Virus (EBV), the virus that causes infectious mononucleosis. In a study published in Science Translational Me…
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The Wistar Institute and Anixa Biosciences Extend Collaborative Research Agreement

Philadelphia and San Jose, Calif. – (Feb. 21, 2019) – The Wistar Institute has extended its collaboration with Anixa Biosciences, Inc. (NASDAQ: ANIX), a biotechnology company focused on using the body’s immune system to fight cancer. The project is…
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New Insight Into the Balance Between the Tumor-suppressive and Tumor-promoting Effects of Cellular Senescence

PHILADELPHIA — (Feb. 18, 2019) — Researchers at The Wistar Institute have described a novel role of nicotinamide adenine dinucleotide (NAD+) metabolism in the ability of senescent cells to release tumor-promoting molecules. This study, published onl…
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You Are What You Eat: Linking Nutrition, Metabolism and Cancer

As the obesity epidemic climbs, and the connection between nutrition and its effects on health risks and outcomes are top of mind, Wistar’s most recent Women & Science Program featured a comprehensive talk on how what we eat is used by our cells…
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Wistar’s David B. Weiner, Ph.D., Awarded Prestigious Scientific Achievement Award from Life Sciences Pennsylvania

PHILADELPHIA — (Feb. 15, 2019) — David B. Weiner, Ph.D., executive vice president, director of the Vaccine & Immunotherapy Center, and the W.W. Smith Charitable Trust Professor in Cancer Research at The Wistar Institute, has been named the recip…