Article list in PubMed (link)


Structural and Functional Analysis of an OB-Fold in Human Ctc1 Implicated in Telomere Maintenance and Bone Marrow Syndromes; Prashanth K. Shastrula, Cory T. Rice, Zhuo Wang, Paul M. Lieberman, and Emmanuel Skordalakes; Nucleic Acid Research (2017); Accepted

Sakurai M, Shiromoto Y, Ota H, Song C, Kossenkov AV, Wickramasinghe J, Showe LC, Skordalakes E, Tang HY, Speicher DW, Nishikura K. ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay. Nat Struct Mol Biol. 2017 Apr 24. doi: 10.1038/nsmb.3403.

Rice C, Shastrula PK, Kossenkov AV, Hills R, Baird DM, Showe LC, Doukov T, Janicki S, Skordalakes E. Structural and functional analysis of the human POT1-TPP1 telomeric complex. Nature Communications. 2017, April 10; 8:14928.

Hoffman H, Rice C, Skordalakes E. Structural analysis reveals the deleterious effects of telomerase mutations in bone marrow failure syndromes. J Biol Chem. 2017 Feb 1.

Hoffman H, Skordalakes E. Crystallographic Studies of Telomerase. Methods Enzymol. 2016;573:403-19. Epub 2016 May 10.

Rice C, Skordalakes E. Structure and function of the telomeric CST complex. Comput Struct Biotechnol J. 2016 Apr 14;14:161-7. Review.

Zhu H, Ren S, Bitler BG, Aird KM, Tu Z, Skordalakes E, Zhu Y, Yan J, Sun Y, Zhang R. SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase. Cell Rep. 2015 Nov 10;13(6):1183-93.

Bryan C, Rice C, Hoffman H, Harkisheimer M, Sweeney M, and Emmanuel Skordalakes. Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532. Structure. 2015 Oct 6;23(10):1934-42.

Greetham M, Skordalakes E, Lydall D, Connolly BA. The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases. J Mol Biol. 2015 Aug 8.

Iwasaki O, Tanizawa H, Kim KD, Yokoyama Y, Corcoran CJ, Tanaka A, Skordalakes E, Showe LC, Noma KI. Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes. Mol Cell. 2015 Aug 5.

Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Science Signaling. 2015 Jun 16;8(381).

Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KL, Rauscher FJ 3rd. LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. Cancer Res. 2014  Mar 1;74(5):1390-403.

Harkisheimer M, Mason M, Shuvaeva E, Skordalakes E. A Motif in the Vertebrate Telomerase N-terminal Linker of TERT Contributes to RNA Binding and Telomerase Activity and Processivity. Structure. 2013; 21, 1–9.

Newhart A, Rafalska-Metcalf IU, Yang T, Joo LM, Powers SL, Kossenkov AV, Lopez-Jones M, Singer RH, Showe LC, Skordalakes E, Janicki SM. Single-cell analysis of RNA-mediated histone H3.3 recruitment to a cytomegalovirus promoter-regulated transcription site. J Biol Chem. 2013 Jul 5;288(27):19882-99. PMCID: PMC3707690

Bryan C, Rice C, Harkisheimer M, Schultz DC, Skordalakes E. Structure of the Human Telomeric Stn1-Ten1 Capping Complex. PLoS One. 2013 Jun 24;8(6). PMCID: PMC3691326

Mason M, Wanat JJ, Harper S, Schultz DC, Speicher DW, Johnson FB, Skordalakes E. Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance. Structure. 2013 Jan 8;21(1):109-20. PMCID: PMC3545062. Accompanying Review, Marita Cohn; OB Fold Contributes to Telomere Maintenance. Structure, Volume 21, Issue 1, 8 January 2013, Pages 3-4.

Skordalakes, E. and Lue, N. F. TERT Structure, Function, and Molecular Mechanisms, in Telomerases: Chemistry, Biology, and Clinical Applications (eds N. F. Lue and C. Autexier), John Wiley & Sons, Inc., (2012), Hoboken, NJ, USA. doi: 10.1002/9781118268667.ch3

Schuller AP, Harkisheimer MJ, Skordalakes EIn vitro Reconstitution of the Active T. castaneum Telomerase. J Vis Exp. 2011 Jul 14;(53). PMCID: PMC3196162

Mason M, Schuller A, Skordalakes E. Telomerase structure function. Curr Opin Struct Biol. 2011 Feb;21(1):92-100. Epub 2010 Dec 17. Review. PubMed PMID: 21168327.

Mitchell MT, Smith JS, Mason M, Harper S, Speicher DW, Johnson FB, Skordalakes E. Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation. Mol Cell Biol. 2010 Nov;30(22):5325-34. Epub 2010 Sep 13. PMCID: PMC2976383.

Song Y, Willer JR, Scherer PC, Panzer JA, Kugath A, Skordalakes E, Gregg RG, Willer GB, Balice-Gordon RJ. Neural and synaptic defects in slytherin, a zebrafish model for human congenital disorders of glycosylation. PLoS One. 2010 Oct 29;5(10):e13743. PMCID: PMC2966427.

Mason M, Skordalakes E. Insights into Cdc13 dependent telomere length regulation. Aging (Albany NY). 2010 Oct;2(10):731-4. PMCID: PMC2993802.

Mitchell M, Gillis A, Futahashi M, Fujiwara H, Skordalakes E. Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA. Nat Struct Mol Biol. 2010 Apr;17(4):513-8. Epub 2010 Mar 28. PubMed PMID: 20357774.

McCray BA, Skordalakes E, Taylor JP. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Hum Mol Genet. 2010 Mar 15;19(6):1033-47. Epub 2009 Dec 22. PMCID: PMC2830827.

Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS. Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21573-8. Epub 2009 Dec 4. PMCID: PMC2799888.

Skordalakes E. Telomerase structure paves the way for new cancer therapies. Future Oncol. 2009 Mar;5(2):163-7. Review. PubMed PMID: 19284375.

Skordalakes E. Telomerase and the benefits of healthy living. Lancet Oncol. 2008 Nov;9(11):1023-4.

Gillis AJ, Schuller AP, Skordalakes E. Structure of the Tribolium castaneum telomerase catalytic subunit TERT. Nature. 2008 Oct 2;455(7213):633-7. Epub 2008 Aug 31.

Carlson BL, Ballister ER, Skordalakes E, King DS, Breidenbach MA, Gilmore SA, Berger JM, Bertozzi CR. Function and structure of a prokaryotic formylglycine-generating enzyme. J Biol Chem. 2008 Jul 18;283(29):20117-25. Epub 2008 Apr 4. PMCID: PMC2459300.

Rouda S, Skordalakes E. Structure of the RNA-binding domain of telomerase: implications for RNA recognition and binding. Structure. 2007 Nov;15(11):1403-12.

Young TA, Skordalakes E, Marqusee S. Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability. J Mol Biol. 2007 May 18;368(5):1438-47. Epub 2007 Mar 6.

Skordalakes E, Berger JM. Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor. Cell. 2006 Nov 3;127(3):553-64.

Skordalakes E, Brogan AP, Park BS, Kohn H, Berger JM. Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin. Structure. 2005 Jan;13(1):99-109.

Daganzo SM, Erzberger JP, Lam WM, Skordalakes E, Zhang R, Franco AA, Brill SJ, Adams PD, Berger JM, Kaufman PD. Structure and function of the conserved core of histone deposition protein Asf1. Curr Biol. 2003 Dec 16;13(24):2148-58.

Skordalakes E, Berger JM. Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading. Cell. 2003 Jul 11;114(1):135-46.

Hansen CL, Skordalakes E, Berger JM, Quake SR. A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16531-6. Epub 2002 Dec 16. PMCID: PMC139178.