Biomarkers and Targets

We are currently developing biomarkers that serve different functions:

1. Selection of patients for therapy
2. Follow-up of patients after initiating therapy
3. Long-term follow-up for therapy outcome.
4. Selecting new targets for therapy
5. Outcome prediction 

Related References:

1 - Lin, W.M., Baker, A.C., Beroukhim, R., Winkler, W., Feng, W., Marmion, J., Laine, E., Greulich, H., Tseng, H., Gates, C., Hodi, F.S., Dranoff, G. M., Sellers, W. R., Thomas, R. K., Meyerson, M., Golub, T. R., Dummer, R., Herlyn, M., Getz, G., Garraway, L.A.: Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res. 68: 664-673, 2008. PMID18245465

2 - Han, M.-J., Herlyn, M., Fisher, A.B. Speicher, D. W.: Microscale solution IEF combined with 2-D DIGE substantially enhances analysis depth of complex proteomes such as mammalian cell and tissue extracts. Electrophoresis 29: 695-705, 2008. PMID18186533

3 - Greshok, J., Nathanson K., Medina, A., Ward, M.R., Herlyn, M., Weber, B.L., Zaks, T.Z.: Distinct patterns of DNA copy number alterations associate with BRAF mutations in melanomas and melanoma derived cell lines. Genes, Chromosomes and Cancer, 48: 419-428 2009. PMID19226609 (PMC2885833)

4 - Degenhardt, Y., Huang, J., Horiates, G., Nathanson, K., Yang, X., Herlyn, M., Weber, B.: Distinct MHC gene expression patterns during progression of melanoma. Genes, Chromosomes, Cancer: 49:144-154, 2010. PMID19907984 (PMC2796267)

5 - Fukunaga-Kalabis, M., Martinez, G., Nguyen, T-T.K, Kim, D., Santiago-Walker, A., Roesch, A., Herlyn, M.: Tenascin promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene 29: 6115-6124, 2010. PMID 2072997

6 - Aggarwal, P., Vaites, L.P., Kim, J. K., Mellert, H., Nakagawa, H., Herlyn, M., Rustgi, A., McMahon, S.B., Diehl, J.A.: Nuclear Cyclin D1/CDK4 minase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell 18: 329-340, 2010. PMID 20951943 (PMC2957477)

7 - Han, M-J., Wang, H., Beer, L.A., Tang, H-Y., Herlyn, M., Speicher, D.: A systems biology analysis of metastatic melanoma using in-depth three-dimensional protein profiling. Proteomics 10: 4450-4462, 2010. PMID21082759

8 - Bogenrieder, T., and Herlyn, M.: The molecular pathology of cutaneous melanoma. Cancer Biomark 9: 267-286, 2011. PMID22112480