Luis J. Montaner, D.V.M., D.Phil.

Luis J. Montaner, D.V.M., D.Phil.

  • Vice President, Scientific Operations
  • Herbert Kean, M.D., Family Endowed Chair Professor
  • Director, HIV-1 Immunopathogenesis Laboratory
  • Professor, Immunology, Microenvironment and Metastasis Program
  • Associate Director for Shared Facilities, Wistar Cancer Center
  • 215-898-9143, Office
Summary

Luis Montaner, D.V.M., M.Sc., D.Phil., studies the mechanisms of disease in HIV-1 infection, and explores new ways to boost the natural function of the immune system in order to combat infection or viral-associated disease.

Montaner obtained his D.V.M., Veterinary Medicine at Kansas State University in 1989, and his D. Phil., in Experimental Pathology at University of Oxford, Oxford, UK in 1995.  He joined The Wistar Institute in 1995 as an assistant professor, and was promoted to professor in 2007.

At Wistar, the Montaner laboratory combines virological and immune system-based research using laboratory models of virus infection and by working with patients enrolled in clinical trials. Their scientific collaborations—and thus, their impact—extend from Philadelphia to California, Puerto Rico, Mexico, and Southern Africa, and focus on:

• identifying new mechanisms of immunodeficiency and discovering new approaches to reverse them by enhancing the response of the immune system.


• exploring new ways to manage current HIV-1 therapies, such as studying how to develop immune-mediated control of infection upon interrupting drug therapy.


• understanding the natural ability of our immune system to respond to viruses and comparing that to the immune response of a rare subset of people who are exposed to—yet uninfected by—HIV-1 or are infected yet retain an inherent ability to control their HIV-1 infection.

Montaner is a sought after national and international lecturer, and has published more than 100 manuscripts in highly prestigious peer reviewed journals such as the Proceedings of the National Academy of Sciences, the Journal of Immunology, the Journal of Virology, the Journal of Infectious Diseases, Blood, and the Journal of Biological Chemistry. Montaner serves as a reviewer for scientific projects for multiple national and international entities. He is also Editor-in-Chief of the Journal of Leukocyte Biology, a recognized international scientific journal in the field.

Selected Publications (2013-present)

1. Tomescu C, Mavilio D and Montaner LJ. Lysis of HIV-1 nfected autologous CD4+ primary t cells by Interferon-alpha activated NK cells requires NKp46 and NKG2D. AIDS. 2015 Sep 10;29(14):1767-73.

2. Papasavvas E, Foulkes A, Yin X, Joseph J, Ross B, Azzoni L, Kostman J, Montaner LJ. PDC and functional HIV Gag p55-specific T cells before treatment interruption can inform set-point plasma HIV viral load after treatment interruption in Chronically Suppressed HIV-1. Immunology. 2015 Jul;145(3):380-90.

3. Tomescu C, Seaton K, Smith, P., Taylor, M., Tomaras, G.D., Metzger, D.S., Montaner, L.J., 2014. Innate Activation of MDC and NK Cells in High-risk HIV-1 Exposed, Sero-Negative (HESN) IV-Drug Users that Share Needles When Compared to Non-sharing IV-Drug User Controls. J Acquir Immune Defic Syndr. 68(3):264-74.

4. Patro SC, Pal S, Bi Y, Lynn K, Mounzer KC, Kostman JR, Davuluri RV, Montaner LJ. Shift in Monocyte Apoptosis with Increasing Viral Load and Change in Apoptosis-related ISG/Bcl2-family Gene Expression in Chronic HIV-1 Infected Subjects. J. Virol. 2015;89(1):799-810.

5. Gekonge B. Bardin MC, Montaner LJ. Nitazoxanide inhibits HIV viral replication in monocyte-derived macrophages.  AIDS Res Hum Retr. 2014;31(2):237-41.

6. Demers A, Kang G, Ma F, Lu W, Yuan Z, Li Y, Lewis M, Kraiselburd EN, Montaner L, Li Q. The Mucosal Expression Pattern of Interferon-ε in Rhesus Macaques.  J. Leukoc. Biol. 2014;96(12):1-7.

7. Tomescu C, Ross BN, Lynn K, Mounzer KC, Kostman JR, Montaner LJ. A Correlate of HIV-1 Control Consisting of Both Innate and Adaptive Immune Parameters Best Predicts Viral Load by Multivariable Analysis in HIV-1 Infected Viremic Controllers and Chronically-Infected Non-Controllers. PLoS One. 2014;31;9(7):e103209.

8. Dawany N, Showe LC, Kossenkov AV, Chang C, Ive P, Conradie F, Stevens WS, Sanne I, Azzoni L, Montaner LJ. Identification of a 251 Gene Expression Signature that Can Accurately Detect M. tuberculosis in Patients with and with HIV Co-infection. PLoS One. 2014;9(2):e89925.

9. Abdulhaqq S, Martinez MI, Kang G, Foulkes AS, Rodriguez IV, Nichols SM, Hunter M, Sariol C, Ruiz LA, Ross BN, Yin X, Speicher DW, Haase A, Marx PA, Li Q, Kraiselburd E, Montaner LJ. Serial Cervicovaginal Exposures With Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated With Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques. J Acquir Immune Defic Syndr. 2014;65(4):405-13.

10. Stevenson JP, Kindler HL, Jacobs-Small M, Hull J, Schwed D, Ranganathan A, Papasavvas E, Montaner LJ, Sun J, Heitjan DF, Langer CJ, McPherson JM, Albelda SM.  Immunological effects of the TGFβ-blocking antibody GC1008 in malignant pleural mesothelioma patients. Oncoimmunology. 2013;2(8):e26218.

11. Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, O'Doherty U, Kostman J, Montaner LJ. Reply to zurWiesch and van Lunzen. J Infect Dis. 2013;208(2):363.

12. Chhatre S, Metzger DS, Frank I, Boyer J, Thompson E, Nidich S, Montaner LJ, Jayadevappa R. Effects of behavioral stress reduction Transcendental Meditation intervention in persons with HIV. AIDS Care. 2013;25(10):1291-7.

13. Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, Busch MP, Deeks SG, Carrington M, O'Doherty U, Kostman J, Montaner LJ. Pegylated Interferon-α2A mono-therapy results in suppression of HIV-1 replication and decreased cell-associated HIV DNA integration. J. Infect. Dis. 2013;207(2): 213-22.

14. Tebas P, Stein D, Binder-Scholl G, Mukherjee R, Brady T, Rebello T, Humeau L, Papasavvas E, Montaner LJ, Schullery D, Shaheen, F, Brennan AL, Zheng Z, Cotte J, Slepushkin V, Veloso E, Mackley A, Hwang WT, Aberra F, Zhan J, Boyer J, Collman RG, Bushman FD, Levine BL, June CH. Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long anti-sense to HIV. Blood. 2013; 121(9):1524-33.