The Sarma Laboratory
The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function. The lab investigates consequences of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination of biochemistry, cell and molecular biology with genome wide approaches to gain mechanistic insight into how chromatin architecture is modified in disease. The goal is to identify new pathways and interactions that can be targeted to correct these epigenetic perturbations.
Qingqing Yan, Ph.D
Nicole Medeiros, M.S.
Current research interests in the lab include:
- Role of RNA interactions in modulation of gene expression and genome organization
- Regulation of the epigenetic landscape by the formation and resolution of RNA-containing chromatin structures
- Differential histone variant deposition in normal and disease states and their impact on gene expression programs and genome stability