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Kavitha Sarma, Ph.D.

Kavitha Sarma, Ph.D.

Laboratory

The Sarma Laboratory

Contact

215-898-3970
ksarma@wistar.org

Assistant Professor, Gene Expression & Regulation Program

About the Scientist

Sarma studies the mechanisms of RNA-mediated epigenetic gene regulation to understand how the loss of chromatin modifier-RNA interactions impacts cellular function.

Sarma completed her graduate studies with a Ph.D. in biochemistry from Rutgers University. She conducted her postdoctoral training at the Massachusetts General Hospital-Harvard Medical School, and joined The Wistar Institute in 2016 as an Assistant Professor.

View Publications

The Sarma Laboratory

The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function. The lab investigates consequences of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination of biochemistry, cell and molecular biology with genome wide approaches to gain mechanistic insight into how chromatin architecture is modified in disease. The goal is to identify new pathways and interactions that can be targeted to correct these epigenetic perturbations.

Staff

Postdoctoral Fellow

Qingqing Yan, Ph.D

Research Assisant

Nicole Medeiros, M.S.

Undergraduate Researchers

Joyce Bian
Devinne Miller

Research

Current research interests in the lab include:

  • Role of RNA interactions in modulation of gene expression and genome organization
  • Regulation of the epigenetic landscape by the formation and resolution of RNA-containing chromatin structures
  • Differential histone variant deposition in normal and disease states and their impact on gene expression programs and genome stability