Our Science

Luis J. Montaner, D.V.M., D.Phil.

Luis J. Montaner, D.V.M., D.Phil.

  • Professor and Director, HIV-1 Immunopathogenesis Laboratory
  • Member, Tumor Microenvironment and Metastasis Program
  • Associate Director for Shared Facilities, Wistar Cancer Center
  • Scientific Director, Flow Cytometry Facility
  • 215-898-9143, Office
Summary

Luis Montaner, D.V.M., M.Sc., D.Phil., studies the mechanisms of disease in HIV-1 infection, and explores new ways to boost the natural function of the immune system in order to combat infection or viral-associated disease.

Montaner obtained his D.V.M., Veterinary Medicine at Kansas State University in 1989, and his D. Phil., in Experimental Pathology at University of Oxford, Oxford, UK in 1995.  He joined The Wistar Institute in 1995 as an assistant professor, and was promoted to professor in 2007.

At Wistar, the Montaner laboratory combines virological and immune system-based research using laboratory models of virus infection and by working with patients enrolled in clinical trials. Their scientific collaborations—and thus, their impact—extend from Philadelphia to California, Puerto Rico, Mexico, and Southern Africa, and focus on:

• identifying new mechanisms of immunodeficiency and discovering new approaches to reverse them by enhancing the response of the immune system.


• exploring new ways to manage current HIV-1 therapies, such as studying how to develop immune-mediated control of infection upon interrupting drug therapy.


• understanding the natural ability of our immune system to respond to viruses and comparing that to the immune response of a rare subset of people who are exposed to—yet uninfected by—HIV-1 or are infected yet retain an inherent ability to control their HIV-1 infection.

Montaner is a sought after national and international lecturer, and has published in excess of 90 manuscripts in highly prestigious peer reviewed journals such as the Proceedings of the National Academy of Sciences, the Journal of Immunology, the Journal of Virology, the Journal of Infectious Diseases, Blood, and the Journal of Biological Chemistry. Montaner serves as a reviewer for scientific projects for multiple national and international entities. He is also Editor-in-Chief of the Journal of Leukocyte Biology, a recognized international scientific journal in the field.

Selected Publications

1 - Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, Busch MP, Deeks SG, Carrington M, O'Doherty U, Kostman J, Montaner LJ. Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration. J Infect Dis. 2013 Jan;207(2):213-22. Epub 2012 Oct 26. 23105144

2 - Sariol CA, Martinez MI, Rivera F, Rodriguez IV, Pantoja P, Abel K, Arana T, Giavedoni L, Hodara V, White LJ, Anglero YI, Montaner LJ, Kraiselburd EN., Decreased Dengue replication and an increased Anti-viral Humoral Response with the use of combined Toll-like Receptor 3 and 7/8., PLoS One. 2011 Apr 29;6(4):e19323., 21559444

3 - Papasavvas E, Azzoni L, Foulkes A, Violari A, Cotton MF, Pistilli M, Reynolds G, Yin X, Glencross DK, Stevens WS, McIntyre JA, Montaner LJ., Increased microbial translocation in ≤ 180 days old perinatally human immunodeficiency virus-positive infants as compared with human immunodeficiency virus-exposed uninfected infants of similar age. Pediatr Infect Dis J. 2011 Oct;30(10):877-82. 21552185

4 - Patro SC, Montaner LJ., Editorial: Is HIV-1 induction of macrophage expression of PD-L1 and PD-L1 its weakest or strongest link to disease? HIV-1 plays both sides by augmenting and limiting T cell activation to survive in vivo., Journal of Leukocyte Biology. 2011 Apr;89(4):495-8., 21454360

5 - Tomescu C, Abdulhaqq S, Montaner LJ., Evidence for the innate immune response as a correlate of protection in Human Immunodeficiency Virus (HIV)-1 highly exposed seronegative subjects (HESN)., Clinical and Experimental Immunology. 2011 May;164(2):158-69. doi: 10.111/j.1365-2249.2011.04379x. [Epub 2011 Mar 17.], 21413945

6 - Azzoni L, Crowther NJ, Firnhaber C, Foulkes AS, Yin X, Glencross D, Gross R, Kaplan MD, Papasavvas E, Schulze D, Stevens W, van der Merwe T, Waisberg R, Sanne I, Montaner LJ., Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV-1-infected South African women., Journal of the International AIDS Society. 2010 Sep 7;13(1):33., 20822522

7 - Papasavvas E, Chehimi J, Azzoni L, Pistilli M, Thiel B, Mackiewicz A, Creer S, Mounzer K, Kostman JR, Montaner LJ., Retention of functional DC-NK cross-talk following up to 18 weeks therapy interruptions in chronically suppressed HIV Type1(+) subjects., AIDS Research and Human Retroviruses. 2010 Aug. 18. [Epub ahead of print], 20718621

8 - Tomescu C, Duh FM, Lanier MA, Kapalko A, Mounzer KC, Martin MP, Carrington M, Metzger DS, Montaner LJ., Increased plasmacytoid dendritic cell maturation and natural killer cell activation in HIV-1 exposed, uninfected intra-venous drug users., AIDS. 2010 Sep 10;24(14):2151-60. [Epub 2010 Jul 17], 20647906

9 - Raymond AD, Gekonge B, Giri MS, Hancock A, Papasavvas E, et al., Showe L, Montaner LJ., Increased Metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia., Journal of Leukocyte Biology. 2010 Sep;88(3):589-96. [Epub 2010 Jun 15], 20551211

10 - Ye L, Wang X, Metzger DS, Riedel E, Montaner LJ, Ho W., Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users., PLoS One. 2010 Mar 9;5(3):e9602., 20231901

11 - Eliot M, Azzoni L, Firnhaber C, Stevens W, Glencross DK, Sanne I, Montaner LJ, Foulkes AS., Tree-based methods for discovery of association between flow cytometry data and clinical endpoints., Advances in Bioinformatics. 2009;2009:235320. [Epub 2010 Jan 21], 20145719