Our Science

Louise C. Showe, Ph.D.

Louise C. Showe, Ph.D.

  • Professor, Molecular and Cellular Oncogenesis Program
  • Associate Director, Center for Systems and Computational Biology
  • Scientific Director, Genomics Facility
  • Scientific Director, Bioinformatics Facility
  • 215-898-3791, Office
Summary

Louise Showe received her bachelor’s degree in biology from Wilkes College (PA) and her master’s in developmental biology from Temple University. After gaining her Ph.D. in biology from the University of Pennsylvania, she moved to Europe to do her postdoctoral studies at the Biozentrum der Universitat, Basel, Switzerland. Dr. Showe joined The Wistar Institute in 1983 as an assistant professor.  She is presently a Professor in the Molecular and Cellular Oncogenesis program and the Scientific Director of the Wistar Bioinformatics and Genomics Shared Resources. She is also the associate director of the Wistar Center for Systems and Computational Biology. Showe was awarded one of the first ten National Cancer Institute Director’s Challenge grants to create new molecular criteria for the classification of cancers using microarrays and is presently funded by the Early Detection Research Network (EDRN) to continue this work.  The technology has been licensed by Oncocyte. 

Showe’s current research interests have focused on using genomics-based approaches and big data to better understand disease processes with an emphasis on the immune system and cancer. In addition, her laboratory has actively contributed to the development of genomics and bioinformatics at The Wistar Institute, focusing on the implementation of new methods for the generation and analysis of large and complex datasets.

Among her most recent work is the identification of biomarkers in the blood that indicate the presence of early-stage lung tumors in high risk populations of smokers and ex-smokers with the goal of developing non-invasive tests that will help to determine whether the large numbers of lung nodules detected by the growing numbers of LDCT scans being carried out each year. They have also used blood gene expression patterns to identify patterns that indicate which lung cancer patients are more likely to relapse after lung surgery, alerting clinicians to re-evaluate further treatment options. Additional studies have also investigated gene expression patterns in malignant and normal immune cells of CTCL patients in response to different treatments both in vivo and in vitro. The group’s diverse interests are shown by a long-term collaboration with the University of Fairbanks to study how hibernating black bears modify gene expression in various tissues during hibernation and her work with the University of Nottingham on multiple sclerosis.

Selected Publications

1 - Yousef M, Ketany M, Manevitz L, Showe LC, Showe MK. Classification and biomarker identification using gene network modules and support vector machines. BMC Bioinformatics. 2009 Oct 15;10:337. 19832995

2 - Showe MK, Vachani A, Kossenkov AV, Yousef M, Nichols C, et al., Speicher D, Rom WN, Albelda S, Showe LC. Gene expression profiles in peripheral blood mononuclear cells can distinguish patients with non-small cell lung cancer from patients with nonmalignant lung disease. Cancer Research. 2009 Dec 15;69(24):9202-10., 19951989

3 - Chakraborty AR, Robey RW, Luchenko VL, Zhan Z, Piekarz RL, Gillet JP, Kossenkov AV, Wilkerson J, Showe LC, Gottesman MM, Collie NL, Bates SE. MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with a MEK inhibitor. Blood. 2013; 121:4115-4125 PMCID: PMC3656450.

4 - Yi C, Shen Z, Stemmer-Rachamimov A, Dawany N, Troutman S, Showe LC, Liu Q, Shimono A, Sudol M, Holmgren L, Stanger BZ, Kissil JL. The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis. Sci Signal. 2013; 6:ra77. PMCID: PMC4175526.

5 - Newhart A, Rafalska-Metcalf IU, Yang T, Joo LM, Powers SL, Kossenkov AV, Lopez-Jones M,  Singer RH, Showe LC, Skordalakes E, Janicki SM. Single Cell Analysis of Rna-Mediated Histone H3.3 Recruitment to a Cytomegalovirus Promoter-Regulated Transcription Site. J Biol Chem. 2013; 288:19882-19899. PMCID: PMC3707690.

6 - Tavecchio M, Lisanti S, Lam A, Ghosh JC, Martin NM, O'Connell M, Weeraratna AT, Kossenkov AV, Showe LC, Altieri DC. Cyclophilin D Extramitochondrial Signaling Controls Cell Cycle Progression and Chemokine-Directed Cell Motility. J Biol Chem. 2013; 288:5553-5561. PMCID: PMC3581434.

7 - Wysocka M, Kossenkov AV, Benoit BM, Troxel AB, Singer E, Schaffer A, Kim B, Dentchev T, Nagata S, Ise T, Showe LC, Rook AH. CD164 and FCRL3 Are Highly Expressed on CD4+CD26- T Cells in Sezary Syndrome Patients. J Invest Dermatol. 2013; 134:229-236. PMCID: PMC3869886.

8 - Pal S, Bi Y, Macyszyn L, Showe LC, O'Rourke DM, Davuluri RV. Isoform-Level Gene Signature Improves Prognostic Stratification and Accurately Classifies Glioblastoma Subtypes. Nucleic Acids Res. 2014; 42:e64. PMCID: PMC3581434.

9 - Wang H, Geng J, Wen X, Bi E, Kossenkov AV, Wolf AI, Tas J, Choi YS, Takata H, Day TJ, Chang LY, Sprout SL, Becker EK, Willen J, T ian L, Wang X, Xiao C, Jiang P, Crotty S, Victora GD, Showe LC, Tucker HO, Erikson J, Hu H. The Transcription Factor Foxp1 Is a Critical Negative Regulator of the Differentiation of Follicular Helper T Cells. Nat Immunol. 2014; 15:667-675. PMCID: PMC4142638.

10 - Gumireddy K, Li A, Kossenkov AV, Cai KQ, Liu Q, Yan J, Xu H, Showe L, Zhang L, Huang Q. ID1 Promotes Breast Cancer Metastasis by S100A9 Regulation. Mol Cancer Res. 2014; 12:1334-1343. PMCID: PMC4163515.

11 - Gourevitch D, Kossenkov AV, Zhang Y, Clark L, Chang C, Showe LC, Heber-Katz E. Inflammation and Its Correlates in Regenerative Wound Healing: An Alternate Perspective. Adv Wound Care. 2014; 3:592-603. PMCID: PMC4152783.

12 - Dawany N, Showe LC, Kossenkov AV, Chang C, Ive P, Conradie F, Stevens W, Sanne I, Azzoni L, Montaner LJ. Identification of a 251 Gene Expression Signature That Can Accurately Detect M. Tuberculosis in Patients with and without HIV Co-Infection. PLoS One. 2014; 9:e89925. PMCID: PMC3934945.

13 - Cheverud JM, Lawson HA, Bouckaert K, Kossenkov AV, Showe LC, Cort L, Blankenhorn EP, Bedelbaeva K, Gourevitch D, Zhang Y, Heber-Katz E. Fine-Mapping Quantitative Trait Loci Affecting Murine External Ear Tissue Regeneration in the LG/J by SM/J Advanced Intercross Line. Heredity. 2014; 112:508-18. PMCID: PMC3998788.

14 - Fedorov VB, Goropashnaya AV, Stewart NC, Tøien O, Chang C, Wang H, Yan J, Showe LC, Showe MK, Barnes BM. Comparative functional genomics of adaptation to muscular disuse in hibernating mammals. Mol Ecol. 2014 Oct 14. doi: 10.1111/mec.12963. [Epub ahead of print]. PMID: 25314618.

15 - Jean-Gilles L, Braitch M, Latif ML, Aram J, Fahey AJ, Edwards LJ, Robins RA, Tanasescu R, Tighe PJ, Gran B, Showe LC, Alexander SP, Chapman V, Kendall DA, Constantinescu CS. Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. Acta Physiol (Oxf). 2015 May;214(1):63-74. doi: 10.1111/apha.12474. Epub 2015 Mar 10.

16 - Iwasaki O, Tanizawa H, Kim KD, Yokoyama Y, Corcoran CJ, Tanaka A, Skordalakes E, Showe LC, Noma K. Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes. Mol Cell. 2015; 59:755-767. PMC4560999.